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Primary Syphilis Presenting As a Chronic Lip Ulcer.
Cureus. 2020 Feb 24; 12(2):e7086.C

Abstract

Syphilis is usually a sexually transmitted infection caused by the spirochete Treponema pallidum. Primary syphilis classically presents as a painless, ulcerated lesion on the genitals. However, the primary lesion is not restricted to this site and appears wherever the spirochete enters through the skin. The symptomatology and appearance of the primary lesion can also vary.  We present a case of a 59-year-old man with a primary syphilitic chancre of the lower lip. The patient was referred to the dermatology clinic by their primary care provider after the ulceration failed to heal with antibiotic therapy. A biopsy of the lesion was taken at this time; the diagnosis of syphilis was then made by histologic examination and immunohistochemical staining. Subsequent serologic tests were also positive. Upon prompting, the patient did report a history of sexually transmitted disease but not of syphilis specifically. The patient was treated with penicillin, and there was clinical improvement of the lesion at the follow-up visit.

Authors+Show Affiliations

School of Medicine, University of Rochester, Rochester, USA.Dermatology, University of Rochester, Rochester, USA.Dermatology, University of Rochester, Rochester, USA.Dermatopathology, University of Rochester, Rochester, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32226687

Citation

Porterfield, Claire, et al. "Primary Syphilis Presenting as a Chronic Lip Ulcer." Cureus, vol. 12, no. 2, 2020, pp. e7086.
Porterfield C, Brodell D, Dolohanty L, et al. Primary Syphilis Presenting As a Chronic Lip Ulcer. Cureus. 2020;12(2):e7086.
Porterfield, C., Brodell, D., Dolohanty, L., & Scott, G. (2020). Primary Syphilis Presenting As a Chronic Lip Ulcer. Cureus, 12(2), e7086. https://doi.org/10.7759/cureus.7086
Porterfield C, et al. Primary Syphilis Presenting as a Chronic Lip Ulcer. Cureus. 2020 Feb 24;12(2):e7086. PubMed PMID: 32226687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary Syphilis Presenting As a Chronic Lip Ulcer. AU - Porterfield,Claire, AU - Brodell,David, AU - Dolohanty,Lindsey, AU - Scott,Glynis, Y1 - 2020/02/24/ PY - 2020/4/1/entrez PY - 2020/4/1/pubmed PY - 2020/4/1/medline KW - biopsy KW - chancre KW - chronic ulcer KW - cutaneous KW - histology KW - oral syphilis KW - primary syphilis KW - skin KW - syphilis KW - treponema pallidum SP - e7086 EP - e7086 JF - Cureus JO - Cureus VL - 12 IS - 2 N2 - Syphilis is usually a sexually transmitted infection caused by the spirochete Treponema pallidum. Primary syphilis classically presents as a painless, ulcerated lesion on the genitals. However, the primary lesion is not restricted to this site and appears wherever the spirochete enters through the skin. The symptomatology and appearance of the primary lesion can also vary.  We present a case of a 59-year-old man with a primary syphilitic chancre of the lower lip. The patient was referred to the dermatology clinic by their primary care provider after the ulceration failed to heal with antibiotic therapy. A biopsy of the lesion was taken at this time; the diagnosis of syphilis was then made by histologic examination and immunohistochemical staining. Subsequent serologic tests were also positive. Upon prompting, the patient did report a history of sexually transmitted disease but not of syphilis specifically. The patient was treated with penicillin, and there was clinical improvement of the lesion at the follow-up visit. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/32226687/Primary_Syphilis_Presenting_As_a_Chronic_Lip_Ulcer L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32226687/ DB - PRIME DP - Unbound Medicine ER -
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