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The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.
Cardiovasc Res. 2020 05 01; 116(6):1097-1100.CR

Abstract

A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.Department of Medical Biostatistics, Center for Applied Statistics, School of Statistics, Renmin University of China, Beijing 100872, China.Department of Emergency, Huashan Hospital, Fudan University, Shanghai 200040, China.Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China.Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32227090

Citation

Chen, Liang, et al. "The ACE2 Expression in Human Heart Indicates New Potential Mechanism of Heart Injury Among Patients Infected With SARS-CoV-2." Cardiovascular Research, vol. 116, no. 6, 2020, pp. 1097-1100.
Chen L, Li X, Chen M, et al. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097-1100.
Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020). The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovascular Research, 116(6), 1097-1100. https://doi.org/10.1093/cvr/cvaa078
Chen L, et al. The ACE2 Expression in Human Heart Indicates New Potential Mechanism of Heart Injury Among Patients Infected With SARS-CoV-2. Cardiovasc Res. 2020 05 1;116(6):1097-1100. PubMed PMID: 32227090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. AU - Chen,Liang, AU - Li,Xiangjie, AU - Chen,Mingquan, AU - Feng,Yi, AU - Xiong,Chenglong, PY - 2020/03/13/received PY - 2020/03/25/accepted PY - 2020/4/1/pubmed PY - 2020/4/29/medline PY - 2020/4/1/entrez KW - ACE2 KW - Heart failure KW - Heart injury KW - SARS-CoV-2 SP - 1097 EP - 1100 JF - Cardiovascular research JO - Cardiovasc. Res. VL - 116 IS - 6 N2 - A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. SN - 1755-3245 UR - https://www.unboundmedicine.com/medline/citation/32227090/The_ACE2_expression_in_human_heart_indicates_new_potential_mechanism_of_heart_injury_among_patients_infected_with_SARS_CoV_2_ L2 - https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvaa078 DB - PRIME DP - Unbound Medicine ER -