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A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis.
Pathol Res Pract. 2020 May; 216(5):152938.PR

Abstract

Disseminated peritoneal leiomyomatosis (DPL) is a rare, benign entity, but DPL following morcellation has become a major concern recently. This study aimed to investigate the molecular relationship between uterine leiomyoma and DPL. We analyzed the clinicopathological and molecular features of 8 DPL patients including 6 (#3-8) with and 2 (#1 and 2) without antecedent morcellation. Patients 1 and 2 were characterized by numerous, small peritoneal nodules whereas patients 4-8 harbored less but larger peritoneal nodules. Patient 3 had a peritoneal carcinomatosis-like dissemination, but she has been alive with disease for 68 months. Histological examination confirmed the diagnosis of leiomyomas in the uterus and extra-uterine sites. Immunohistochemistry demonstrated that both uterine and extra-uterine tumors were invariably positive for HMGA2 and MED12. MED12 mutation (c.130 G > A, p.G44S) was found in original uterine (n = 3) and peritoneal (n = 11) tumors from patients 3, 6, 7 and 8. Microsatellite instability at TPOX and D19S433 was observed in the uterine leiomyoma (patient 2) whereas LOH at CSF1PO was found in the peritoneal tumors (patient 1). D13S317 LOH was present in both uterine and peritoneal tumors detected (patient 8). However, D3S1358 LOH and D19S433 LOH was only found in the peritoneal tumors (patient 8) and recurrent tumors (patient 3), respectively. We suggested that DPLs following morcellation might be closely associated with original uterine leiomyomas. DPLs with and without prior morcellation may harbor different pathogenetic pathways. These findings are critical for the clinical intervention and prevention of DPL patients.

Authors+Show Affiliations

Department of Clinical Laboratory Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address: mayu815@zju.edu.cn.Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address: wangsu423@zju.edu.cn.Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address: rompliuqin@zju.edu.cn.Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address: lbj@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32234244

Citation

Ma, Yu, et al. "A Clinicopathological and Molecular Analysis in Uterine Leiomyomas and Concurrent/metachronous Peritoneal Nodules: New Insights Into Disseminated Peritoneal Leiomyomatosis." Pathology, Research and Practice, vol. 216, no. 5, 2020, p. 152938.
Ma Y, Wang S, Liu Q, et al. A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. Pathol Res Pract. 2020;216(5):152938.
Ma, Y., Wang, S., Liu, Q., & Lu, B. (2020). A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. Pathology, Research and Practice, 216(5), 152938. https://doi.org/10.1016/j.prp.2020.152938
Ma Y, et al. A Clinicopathological and Molecular Analysis in Uterine Leiomyomas and Concurrent/metachronous Peritoneal Nodules: New Insights Into Disseminated Peritoneal Leiomyomatosis. Pathol Res Pract. 2020;216(5):152938. PubMed PMID: 32234244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. AU - Ma,Yu, AU - Wang,Su, AU - Liu,Qin, AU - Lu,Bingjian, Y1 - 2020/03/24/ PY - 2019/12/19/received PY - 2020/02/25/revised PY - 2020/03/21/accepted PY - 2020/4/3/pubmed PY - 2020/4/3/medline PY - 2020/4/3/entrez KW - Disseminated peritoneal leiomyomatosis KW - MED12 mutation KW - Morcellation KW - Short tandem repeats SP - 152938 EP - 152938 JF - Pathology, research and practice JO - Pathol. Res. Pract. VL - 216 IS - 5 N2 - Disseminated peritoneal leiomyomatosis (DPL) is a rare, benign entity, but DPL following morcellation has become a major concern recently. This study aimed to investigate the molecular relationship between uterine leiomyoma and DPL. We analyzed the clinicopathological and molecular features of 8 DPL patients including 6 (#3-8) with and 2 (#1 and 2) without antecedent morcellation. Patients 1 and 2 were characterized by numerous, small peritoneal nodules whereas patients 4-8 harbored less but larger peritoneal nodules. Patient 3 had a peritoneal carcinomatosis-like dissemination, but she has been alive with disease for 68 months. Histological examination confirmed the diagnosis of leiomyomas in the uterus and extra-uterine sites. Immunohistochemistry demonstrated that both uterine and extra-uterine tumors were invariably positive for HMGA2 and MED12. MED12 mutation (c.130 G > A, p.G44S) was found in original uterine (n = 3) and peritoneal (n = 11) tumors from patients 3, 6, 7 and 8. Microsatellite instability at TPOX and D19S433 was observed in the uterine leiomyoma (patient 2) whereas LOH at CSF1PO was found in the peritoneal tumors (patient 1). D13S317 LOH was present in both uterine and peritoneal tumors detected (patient 8). However, D3S1358 LOH and D19S433 LOH was only found in the peritoneal tumors (patient 8) and recurrent tumors (patient 3), respectively. We suggested that DPLs following morcellation might be closely associated with original uterine leiomyomas. DPLs with and without prior morcellation may harbor different pathogenetic pathways. These findings are critical for the clinical intervention and prevention of DPL patients. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/32234244/A_clinicopathological_and_molecular_analysis_in_uterine_leiomyomas_and_concurrent/metachronous_peritoneal_nodules:_New_insights_into_disseminated_peritoneal_leiomyomatosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(19)32948-6 DB - PRIME DP - Unbound Medicine ER -
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