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Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients.
Biol Pharm Bull. 2020; 43(4):682-687.BP

Abstract

We previously showed that adhesive aggregates were formed when levofloxacin hydrate tablets and lansoprazole orally disintegrating (OD) tablets were suspended in water in the clinical context. In this study, we have clarified the factors causing aggregate formation, focusing on the role of pharmaceutical additives and electrostatic interaction. Co-suspension of enteric-coated proton pump inhibitor (PPI) esomeprazole magnesium hydrate with levofloxacin resulted in aggregate formation, whereas the non-enteric-coated PPI vonoprazan fumarate did not. A comparison of pharmaceutical additive in the two PPIs highlighted polysorbate 80 and methacrylic acid copolymer LD as candidates causing aggregation. When these pharmaceutical additives were added to levofloxacin, only methacrylic acid copolymer LD induced aggregate formation. Since levofloxacin is zwitterionic, we examined another zwitterionic ingredient, ampicillin sodium, and found that it also formed aggregates with methacrylic acid copolymer LD, while benzylpenicillin sodium, which is not zwitterionic, did not form aggregates. When we next examined a series of zwitterionic quinolone antimicrobial drugs, we found that ofloxacin, which is highly soluble, formed aggregates with lansoprazole OD tablets, whereas poorly soluble quinolone antimicrobial drugs did not form aggregates. Further, although cefepime hydrochloride and cephalexin did not form aggregates with methacrylic acid copolymer LD in tap water, aggregates were formed when a suspension of cefepime hydrochloride or cephalexin with methacrylic acid copolymer LD was adjusted to pH 7.0. Our results indicate that electrostatic interaction between zwitterionic ingredients and methacrylic acid copolymer LD can result in aggregate formation under conditions where the drug and methacrylic acid copolymer LD are both sufficiently soluble.

Authors+Show Affiliations

Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University. Department of Hospital Pharmacy, University Hospital, Kanazawa University.Department of Hospital Pharmacy, University Hospital, Kanazawa University.Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical & Health Science, Kanazawa University.Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University. Department of Hospital Pharmacy, University Hospital, Kanazawa University.Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University. Department of Hospital Pharmacy, University Hospital, Kanazawa University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32238709

Citation

Nakagawa, Yukiko, et al. "Examination of Aggregate Formation Upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients." Biological & Pharmaceutical Bulletin, vol. 43, no. 4, 2020, pp. 682-687.
Nakagawa Y, Suzuki T, Suga Y, et al. Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. Biol Pharm Bull. 2020;43(4):682-687.
Nakagawa, Y., Suzuki, T., Suga, Y., Shimada, T., & Sai, Y. (2020). Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. Biological & Pharmaceutical Bulletin, 43(4), 682-687. https://doi.org/10.1248/bpb.b19-00924
Nakagawa Y, et al. Examination of Aggregate Formation Upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. Biol Pharm Bull. 2020;43(4):682-687. PubMed PMID: 32238709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. AU - Nakagawa,Yukiko, AU - Suzuki,Takuya, AU - Suga,Yukio, AU - Shimada,Tsutomu, AU - Sai,Yoshimichi, PY - 2020/4/3/entrez PY - 2020/4/3/pubmed PY - 2020/4/3/medline KW - aggregation KW - electrostatic interaction KW - levofloxacin KW - methacrylic acid copolymer LD KW - zwitterionic ingredient SP - 682 EP - 687 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 43 IS - 4 N2 - We previously showed that adhesive aggregates were formed when levofloxacin hydrate tablets and lansoprazole orally disintegrating (OD) tablets were suspended in water in the clinical context. In this study, we have clarified the factors causing aggregate formation, focusing on the role of pharmaceutical additives and electrostatic interaction. Co-suspension of enteric-coated proton pump inhibitor (PPI) esomeprazole magnesium hydrate with levofloxacin resulted in aggregate formation, whereas the non-enteric-coated PPI vonoprazan fumarate did not. A comparison of pharmaceutical additive in the two PPIs highlighted polysorbate 80 and methacrylic acid copolymer LD as candidates causing aggregation. When these pharmaceutical additives were added to levofloxacin, only methacrylic acid copolymer LD induced aggregate formation. Since levofloxacin is zwitterionic, we examined another zwitterionic ingredient, ampicillin sodium, and found that it also formed aggregates with methacrylic acid copolymer LD, while benzylpenicillin sodium, which is not zwitterionic, did not form aggregates. When we next examined a series of zwitterionic quinolone antimicrobial drugs, we found that ofloxacin, which is highly soluble, formed aggregates with lansoprazole OD tablets, whereas poorly soluble quinolone antimicrobial drugs did not form aggregates. Further, although cefepime hydrochloride and cephalexin did not form aggregates with methacrylic acid copolymer LD in tap water, aggregates were formed when a suspension of cefepime hydrochloride or cephalexin with methacrylic acid copolymer LD was adjusted to pH 7.0. Our results indicate that electrostatic interaction between zwitterionic ingredients and methacrylic acid copolymer LD can result in aggregate formation under conditions where the drug and methacrylic acid copolymer LD are both sufficiently soluble. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/32238709/Examination_of_Aggregate_Formation_upon_Simultaneous_Dissolution_of_Methacrylic_Acid_Copolymer_LD_Enteric_Coating_Agent,_Pharmaceutical_Additives,_and_Zwitterionic_Ingredients L2 - https://dx.doi.org/10.1248/bpb.b19-00924 DB - PRIME DP - Unbound Medicine ER -
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