Tags

Type your tag names separated by a space and hit enter

The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives.
Int J Mol Sci. 2020 Mar 21; 21(6)IJ

Abstract

After being historically considered as noxious agents, nitric oxide (NO) and hydrogen sulfide (H2S) are now listed as gasotransmitters, gaseous molecules that play a key role in a variety of cellular functions. Both NO and H2S are endogenously produced, enzymatically or non-enzymatically, and interact with each other in a range of cells and tissues. In spite of the great advances achieved in recent decades in other biological systems, knowledge about H2S function and interactions with NO in sperm biology is in its infancy. Here, we aim to provide an update on the importance of these molecules in the physiology of the male gamete. Special emphasis is given to the most recent advances in the metabolism, mechanisms of action, and effects (both physiological and pathophysiological) of these gasotransmitters. This manuscript also illustrates the physiological implications of NO and H2S observed in other cell types, which might be important for sperm function. The relevance of these gasotransmitters to several signaling pathways within sperm cells highlights their potential use for the improvement and successful application of assisted reproductive technologies.

Authors+Show Affiliations

Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6-Suchdol, Czech Republic.Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6-Suchdol, Czech Republic.Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6-Suchdol, Czech Republic.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32245265

Citation

Kadlec, Martin, et al. "The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives." International Journal of Molecular Sciences, vol. 21, no. 6, 2020.
Kadlec M, Ros-Santaella JL, Pintus E. The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives. Int J Mol Sci. 2020;21(6).
Kadlec, M., Ros-Santaella, J. L., & Pintus, E. (2020). The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives. International Journal of Molecular Sciences, 21(6). https://doi.org/10.3390/ijms21062174
Kadlec M, Ros-Santaella JL, Pintus E. The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives. Int J Mol Sci. 2020 Mar 21;21(6) PubMed PMID: 32245265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives. AU - Kadlec,Martin, AU - Ros-Santaella,José Luis, AU - Pintus,Eliana, Y1 - 2020/03/21/ PY - 2020/02/05/received PY - 2020/03/10/revised PY - 2020/03/18/accepted PY - 2020/4/5/entrez PY - 2020/4/5/pubmed PY - 2021/1/14/medline KW - gasotransmitters KW - hydrogen sulfide KW - interaction KW - metabolism KW - nitric oxide KW - spermatozoa JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 6 N2 - After being historically considered as noxious agents, nitric oxide (NO) and hydrogen sulfide (H2S) are now listed as gasotransmitters, gaseous molecules that play a key role in a variety of cellular functions. Both NO and H2S are endogenously produced, enzymatically or non-enzymatically, and interact with each other in a range of cells and tissues. In spite of the great advances achieved in recent decades in other biological systems, knowledge about H2S function and interactions with NO in sperm biology is in its infancy. Here, we aim to provide an update on the importance of these molecules in the physiology of the male gamete. Special emphasis is given to the most recent advances in the metabolism, mechanisms of action, and effects (both physiological and pathophysiological) of these gasotransmitters. This manuscript also illustrates the physiological implications of NO and H2S observed in other cell types, which might be important for sperm function. The relevance of these gasotransmitters to several signaling pathways within sperm cells highlights their potential use for the improvement and successful application of assisted reproductive technologies. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32245265/The_Roles_of_NO_and_H2S_in_Sperm_Biology:_Recent_Advances_and_New_Perspectives_ L2 - https://www.mdpi.com/resolver?pii=ijms21062174 DB - PRIME DP - Unbound Medicine ER -