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Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV.
Int J Infect Dis. 2020 May; 94:119-124.IJ

Abstract

BACKGROUND

The rapid spread of the coronavirus disease 2019 (COVID-19), caused by a zoonotic beta-coronavirus entitled 2019 novel coronavirus (2019-nCoV), has become a global threat. Awareness of the biological features of 2019-nCoV should be updated in time and needs to be comprehensively summarized to help optimize control measures and make therapeutic decisions.

METHODS

Based on recently published literature, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infection.

RESULTS

The genome of 2019-nCoV partially resembled SARS-CoV and MERS-CoV, and indicated a bat origin. The COVID-19 generally had a high reproductive number, a long incubation period, a short serial interval and a low case fatality rate (much higher in patients with comorbidities) than SARS and MERS. Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. Potential treatments included remdesivir, chloroquine, tocilizumab, convalescent plasma and vaccine immunization (when possible).

CONCLUSION

The initial experience from the current pandemic and lessons from the previous two pandemics can help improve future preparedness plans and combat disease progression.

Authors+Show Affiliations

Department of Geriatrics / Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.Department of Geriatrics / Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: qiongch@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32247050

Citation

Xie, Mingxuan, and Qiong Chen. "Insight Into 2019 Novel Coronavirus - an Updated Interim Review and Lessons From SARS-CoV and MERS-CoV." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 94, 2020, pp. 119-124.
Xie M, Chen Q. Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV. Int J Infect Dis. 2020;94:119-124.
Xie, M., & Chen, Q. (2020). Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 94, 119-124. https://doi.org/10.1016/j.ijid.2020.03.071
Xie M, Chen Q. Insight Into 2019 Novel Coronavirus - an Updated Interim Review and Lessons From SARS-CoV and MERS-CoV. Int J Infect Dis. 2020;94:119-124. PubMed PMID: 32247050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV. AU - Xie,Mingxuan, AU - Chen,Qiong, Y1 - 2020/04/01/ PY - 2020/03/08/received PY - 2020/03/23/revised PY - 2020/03/24/accepted PY - 2020/4/5/pubmed PY - 2020/5/21/medline PY - 2020/4/5/entrez KW - 2019- nCoV KW - COVID-19 KW - MERS- CoV KW - SARS-CoV KW - SARS-CoV- 2 SP - 119 EP - 124 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int. J. Infect. Dis. VL - 94 N2 - BACKGROUND: The rapid spread of the coronavirus disease 2019 (COVID-19), caused by a zoonotic beta-coronavirus entitled 2019 novel coronavirus (2019-nCoV), has become a global threat. Awareness of the biological features of 2019-nCoV should be updated in time and needs to be comprehensively summarized to help optimize control measures and make therapeutic decisions. METHODS: Based on recently published literature, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infection. RESULTS: The genome of 2019-nCoV partially resembled SARS-CoV and MERS-CoV, and indicated a bat origin. The COVID-19 generally had a high reproductive number, a long incubation period, a short serial interval and a low case fatality rate (much higher in patients with comorbidities) than SARS and MERS. Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. Potential treatments included remdesivir, chloroquine, tocilizumab, convalescent plasma and vaccine immunization (when possible). CONCLUSION: The initial experience from the current pandemic and lessons from the previous two pandemics can help improve future preparedness plans and combat disease progression. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/32247050/Insight_into_2019_novel_coronavirus___An_updated_interim_review_and_lessons_from_SARS_CoV_and_MERS_CoV_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(20)30204-6 DB - PRIME DP - Unbound Medicine ER -