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Myogenesis control by SIX transcriptional complexes.
Semin Cell Dev Biol. 2020 Aug; 104:51-64.SC

Abstract

SIX homeoproteins were first described in Drosophila, where they participate in the Pax-Six-Eya-Dach (PSED) network with eyeless, eyes absent and dachsund to drive synergistically eye development through genetic and biochemical interactions. The role of the PSED network and SIX proteins in muscle formation in vertebrates was subsequently identified. Evolutionary conserved interactions with EYA and DACH proteins underlie the activity of SIX transcriptional complexes (STC) both during embryogenesis and in adult myofibers. Six genes are expressed throughout muscle development, in embryonic and adult proliferating myogenic stem cells and in fetal and adult post-mitotic myofibers, where SIX proteins regulate the expression of various categories of genes. In vivo, SIX proteins control many steps of muscle development, acting through feedforward mechanisms: in the embryo for myogenic fate acquisition through the direct control of Myogenic Regulatory Factors; in adult myofibers for their contraction/relaxation and fatigability properties through the control of genes involved in metabolism, sarcomeric organization and calcium homeostasis. Furthermore, during development and in the adult, SIX homeoproteins participate in the genesis and the maintenance of myofibers diversity.

Authors+Show Affiliations

Université de Paris, Institut Cochin, INSERM, CNRS, 75014, Paris, France. Electronic address: pascal.maire@inserm.fr.Université de Paris, Institut Cochin, INSERM, CNRS, 75014, Paris, France.Université de Paris, Institut Cochin, INSERM, CNRS, 75014, Paris, France.Research Center for Advanced Science and Technology, The University of Tokyo, Japan.Université de Paris, Institut Cochin, INSERM, CNRS, 75014, Paris, France.Department of Integrative Medical Biology (IMB), Umeå universitet, Sweden.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32247726

Citation

Maire, Pascal, et al. "Myogenesis Control By SIX Transcriptional Complexes." Seminars in Cell & Developmental Biology, vol. 104, 2020, pp. 51-64.
Maire P, Dos Santos M, Madani R, et al. Myogenesis control by SIX transcriptional complexes. Semin Cell Dev Biol. 2020;104:51-64.
Maire, P., Dos Santos, M., Madani, R., Sakakibara, I., Viaut, C., & Wurmser, M. (2020). Myogenesis control by SIX transcriptional complexes. Seminars in Cell & Developmental Biology, 104, 51-64. https://doi.org/10.1016/j.semcdb.2020.03.003
Maire P, et al. Myogenesis Control By SIX Transcriptional Complexes. Semin Cell Dev Biol. 2020;104:51-64. PubMed PMID: 32247726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myogenesis control by SIX transcriptional complexes. AU - Maire,Pascal, AU - Dos Santos,Matthieu, AU - Madani,Rouba, AU - Sakakibara,Iori, AU - Viaut,Camille, AU - Wurmser,Maud, Y1 - 2020/04/01/ PY - 2020/01/07/received PY - 2020/03/10/revised PY - 2020/03/11/accepted PY - 2020/4/6/pubmed PY - 2020/4/6/medline PY - 2020/4/6/entrez KW - Adult myofiber KW - Development KW - Genetic network KW - MyoD KW - Myogenesis KW - Myogenin KW - Pax7 KW - Satellite cell KW - Six1 SP - 51 EP - 64 JF - Seminars in cell & developmental biology JO - Semin. Cell Dev. Biol. VL - 104 N2 - SIX homeoproteins were first described in Drosophila, where they participate in the Pax-Six-Eya-Dach (PSED) network with eyeless, eyes absent and dachsund to drive synergistically eye development through genetic and biochemical interactions. The role of the PSED network and SIX proteins in muscle formation in vertebrates was subsequently identified. Evolutionary conserved interactions with EYA and DACH proteins underlie the activity of SIX transcriptional complexes (STC) both during embryogenesis and in adult myofibers. Six genes are expressed throughout muscle development, in embryonic and adult proliferating myogenic stem cells and in fetal and adult post-mitotic myofibers, where SIX proteins regulate the expression of various categories of genes. In vivo, SIX proteins control many steps of muscle development, acting through feedforward mechanisms: in the embryo for myogenic fate acquisition through the direct control of Myogenic Regulatory Factors; in adult myofibers for their contraction/relaxation and fatigability properties through the control of genes involved in metabolism, sarcomeric organization and calcium homeostasis. Furthermore, during development and in the adult, SIX homeoproteins participate in the genesis and the maintenance of myofibers diversity. SN - 1096-3634 UR - https://www.unboundmedicine.com/medline/citation/32247726/Myogenesis_control_by_SIX_transcriptional_complexes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1084-9521(19)30134-X DB - PRIME DP - Unbound Medicine ER -
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