Tags

Type your tag names separated by a space and hit enter

The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia.
Med Sci Monit. 2020 Apr 05; 26:e919815.MS

Abstract

BACKGROUND

Fructus aurantii is a flavonoid derived from Citrus aurantium (bitter orange) that is used in traditional Chinese medicine (TCM) to treat gastric motility disorders. This study aimed to investigate the effects of low-dose and high-dose decoctions of Fructus aurantii in a rat model of functional dyspepsia (FD). MATERIAL AND

METHODS

Sprague-Dawley rats (n=90) were divided into nine study groups: the control group, the FD model group, the domperidone-treated (Domp) group, the low-dose raw Fructus aurantii (FA-L) group, the high-dose raw Fructus aurantii (FA-H) group, the low-dose Fructus aurantii with stir-fried wheat bran (Bran-L) group, the high-dose Fructus aurantii with stir-fried wheat bran (Bran-H) group, the low-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-L) group, and the high-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-H) group. The FD rat model was established by semi-starvation, followed by tail damping, stimulation, and forced exercise with fatigue. Change in weight, rate of gastric emptying and intestinal propulsion, and serum levels of leptin, motilin, vasoactive intestinal peptide (VIP), gastrin, calcitonin gene-related peptide (CGRP), ghrelin, and cholecystokinin were compared between the groups.

RESULTS

In the FD model group, weight, rate of gastric emptying and intestinal propulsion significantly decreased, the expression of leptin, VIP and CGRP increased, and expression of motilin, gastrin, ghrelin, and cholecystokinin significantly decreased. Treatment with low-dose Fructus aurantii with stir-fried wheat bran significantly reversed these effects.

CONCLUSIONS

In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels.

Authors+Show Affiliations

School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32248203

Citation

Zhu, Jing, et al. "The Effects of Low-Dose and High-Dose Decoctions of Fructus Aurantii in a Rat Model of Functional Dyspepsia." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 26, 2020, pp. e919815.
Zhu J, Tong H, Ye X, et al. The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia. Med Sci Monit. 2020;26:e919815.
Zhu, J., Tong, H., Ye, X., Zhang, J., Huang, Y., Yang, M., Zhong, L., & Gong, Q. (2020). The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 26, e919815. https://doi.org/10.12659/MSM.919815
Zhu J, et al. The Effects of Low-Dose and High-Dose Decoctions of Fructus Aurantii in a Rat Model of Functional Dyspepsia. Med Sci Monit. 2020 Apr 5;26:e919815. PubMed PMID: 32248203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia. AU - Zhu,Jing, AU - Tong,Hengli, AU - Ye,Xide, AU - Zhang,Jinlian, AU - Huang,Yi, AU - Yang,Ming, AU - Zhong,Lingyun, AU - Gong,Qianfeng, Y1 - 2020/04/05/ PY - 2020/4/6/entrez PY - 2020/4/6/pubmed PY - 2020/4/10/medline SP - e919815 EP - e919815 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 26 N2 - BACKGROUND Fructus aurantii is a flavonoid derived from Citrus aurantium (bitter orange) that is used in traditional Chinese medicine (TCM) to treat gastric motility disorders. This study aimed to investigate the effects of low-dose and high-dose decoctions of Fructus aurantii in a rat model of functional dyspepsia (FD). MATERIAL AND METHODS Sprague-Dawley rats (n=90) were divided into nine study groups: the control group, the FD model group, the domperidone-treated (Domp) group, the low-dose raw Fructus aurantii (FA-L) group, the high-dose raw Fructus aurantii (FA-H) group, the low-dose Fructus aurantii with stir-fried wheat bran (Bran-L) group, the high-dose Fructus aurantii with stir-fried wheat bran (Bran-H) group, the low-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-L) group, and the high-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-H) group. The FD rat model was established by semi-starvation, followed by tail damping, stimulation, and forced exercise with fatigue. Change in weight, rate of gastric emptying and intestinal propulsion, and serum levels of leptin, motilin, vasoactive intestinal peptide (VIP), gastrin, calcitonin gene-related peptide (CGRP), ghrelin, and cholecystokinin were compared between the groups. RESULTS In the FD model group, weight, rate of gastric emptying and intestinal propulsion significantly decreased, the expression of leptin, VIP and CGRP increased, and expression of motilin, gastrin, ghrelin, and cholecystokinin significantly decreased. Treatment with low-dose Fructus aurantii with stir-fried wheat bran significantly reversed these effects. CONCLUSIONS In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/32248203/The_Effects_of_Low_Dose_and_High_Dose_Decoctions_of_Fructus_aurantii_in_a_Rat_Model_of_Functional_Dyspepsia_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32248203/ DB - PRIME DP - Unbound Medicine ER -