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Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy.
Analyst. 2020 May 07; 145(9):3440-3446.A

Abstract

Fentanyl and its analogs have been at the center of the opioid epidemic currently wreaking havoc in the United States. One major element in the opioid crisis is the growing number of clandestine fentanyl labs being reported by enforcement agencies. The development of new analytical methods for detecting and identifying fentanyl and its congeners is among the useful tools in our goal to limit the use of this dangerous family of narcotics. Herein we describe an analytical technique using surface-enhanced Raman spectroscopy (SERS) and a microfluidic device, for detecting fentanyl and two of its chemical precursors, despropionylfentanyl (4ANPP) and N-phenethyl-4-piperidinone (NPP). The vibrational spectra of this family of analytes are very similar, making them difficult to distinguish by traditional means. In addition to taking advantage of the sensitivity provided by SERS, we developed a chemometric approach utilizing a hierarchical partial least squares-discriminant analysis algorithm that allowed us to distinguish spectra that possess many similar features.

Authors+Show Affiliations

Department of Biomolecular Science and Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32259176

Citation

Mirsafavi, Rustin, et al. "Detection and Classification of Fentanyl and Its Precursors By Surface-enhanced Raman Spectroscopy." The Analyst, vol. 145, no. 9, 2020, pp. 3440-3446.
Mirsafavi R, Moskovits M, Meinhart C. Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy. Analyst. 2020;145(9):3440-3446.
Mirsafavi, R., Moskovits, M., & Meinhart, C. (2020). Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy. The Analyst, 145(9), 3440-3446. https://doi.org/10.1039/c9an02568e
Mirsafavi R, Moskovits M, Meinhart C. Detection and Classification of Fentanyl and Its Precursors By Surface-enhanced Raman Spectroscopy. Analyst. 2020 May 7;145(9):3440-3446. PubMed PMID: 32259176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy. AU - Mirsafavi,Rustin, AU - Moskovits,Martin, AU - Meinhart,Carl, Y1 - 2020/04/07/ PY - 2020/4/8/pubmed PY - 2021/1/9/medline PY - 2020/4/8/entrez SP - 3440 EP - 3446 JF - The Analyst JO - Analyst VL - 145 IS - 9 N2 - Fentanyl and its analogs have been at the center of the opioid epidemic currently wreaking havoc in the United States. One major element in the opioid crisis is the growing number of clandestine fentanyl labs being reported by enforcement agencies. The development of new analytical methods for detecting and identifying fentanyl and its congeners is among the useful tools in our goal to limit the use of this dangerous family of narcotics. Herein we describe an analytical technique using surface-enhanced Raman spectroscopy (SERS) and a microfluidic device, for detecting fentanyl and two of its chemical precursors, despropionylfentanyl (4ANPP) and N-phenethyl-4-piperidinone (NPP). The vibrational spectra of this family of analytes are very similar, making them difficult to distinguish by traditional means. In addition to taking advantage of the sensitivity provided by SERS, we developed a chemometric approach utilizing a hierarchical partial least squares-discriminant analysis algorithm that allowed us to distinguish spectra that possess many similar features. SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/32259176/Detection_and_classification_of_fentanyl_and_its_precursors_by_surface_enhanced_Raman_spectroscopy_ L2 - https://doi.org/10.1039/c9an02568e DB - PRIME DP - Unbound Medicine ER -