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Association of Muscle Strength and Gait Speed with Cross-Sectional Muscle Area Determined by Mid-Thigh Computed Tomography - A Comparison with Skeletal Muscle Mass Measured by Dual-Energy X-Ray Absorptiometry.
J Frailty Aging. 2020; 9(2):82-89.JF

Abstract

BACKGROUND

Muscle mass is often mentioned not to reflect muscle strength. For muscle mass assessment skeletal muscle index (SMI) is often used. We have reported that dual-energy X-ray absorptiometry (DXA)-derived SMI does not change with age in women, whereas the cross-sectional muscle area (CSMA) derived from computed tomography (CT) does.

OBJECTIVES

The present study aimed to compare CT and DXA for the assessment of muscle tissue.

DESIGN AND SETTING

Cross-sectional study in the local residents.

PARTICIPANTS

A total of 1818 subjects (age 40-89 years) randomly selected from community dwellers underwent CT examination of the right mid-thigh to measure the cross-sectional muscle area (CSMA). Skeletal muscle mass (SMM) was measured by DXA. The subjects performed physical function tests such as grip strength, knee extension strength, leg extension strength, and gait speed. The correlation between CT-derived CSMA and DXA-derived SMM along with their association with physical function was examined.

RESULTS

After controlling for related factors, the partial correlation coefficient of muscle cross-sectional area (CSA) with physical function was larger than that of DXA-derived SMM for gait speed in men (p=0.002) and knee extension strength in women (p=0.03). The partial correlation coefficient of quadriceps (Qc) CSA with physical function was larger than that of DXA-derived SMM for leg extension power in both sexes (p=0.01), gait speed in men (p<0.001), and knee extension strength in women (p<0.001).

CONCLUSION

Mid-thigh CT-derived CSMA, especially Qc CSA, showed significant associations with grip strength, knee extension strength, and leg extension power, which were equal to or stronger than those of DXA-derived SMM in community-dwelling middle-aged and older Japanese people. The mid-thigh CSMA may be a predictor of mobility disability, and is considered to be useful in the diagnosis of sarcopenia.

Authors+Show Affiliations

Yasumoto Matsui, Center for Frailty and Locomotive syndrome, National Center for Geriatrics and Gerontology, 7-430. Morioka-cho, Obu, Aichi, Japan, e-mail address: matsui@ncgg.go.jp, telephone 81-522-046-2311, fax numbers:81-562-44-8518.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32259181

Citation

Tsukasaki, K, et al. "Association of Muscle Strength and Gait Speed With Cross-Sectional Muscle Area Determined By Mid-Thigh Computed Tomography - a Comparison With Skeletal Muscle Mass Measured By Dual-Energy X-Ray Absorptiometry." The Journal of Frailty & Aging, vol. 9, no. 2, 2020, pp. 82-89.
Tsukasaki K, Matsui Y, Arai H, et al. Association of Muscle Strength and Gait Speed with Cross-Sectional Muscle Area Determined by Mid-Thigh Computed Tomography - A Comparison with Skeletal Muscle Mass Measured by Dual-Energy X-Ray Absorptiometry. J Frailty Aging. 2020;9(2):82-89.
Tsukasaki, K., Matsui, Y., Arai, H., Harada, A., Tomida, M., Takemura, M., Otsuka, R., Ando, F., & Shimokata, H. (2020). Association of Muscle Strength and Gait Speed with Cross-Sectional Muscle Area Determined by Mid-Thigh Computed Tomography - A Comparison with Skeletal Muscle Mass Measured by Dual-Energy X-Ray Absorptiometry. The Journal of Frailty & Aging, 9(2), 82-89. https://doi.org/10.14283/jfa.2020.16
Tsukasaki K, et al. Association of Muscle Strength and Gait Speed With Cross-Sectional Muscle Area Determined By Mid-Thigh Computed Tomography - a Comparison With Skeletal Muscle Mass Measured By Dual-Energy X-Ray Absorptiometry. J Frailty Aging. 2020;9(2):82-89. PubMed PMID: 32259181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Muscle Strength and Gait Speed with Cross-Sectional Muscle Area Determined by Mid-Thigh Computed Tomography - A Comparison with Skeletal Muscle Mass Measured by Dual-Energy X-Ray Absorptiometry. AU - Tsukasaki,K, AU - Matsui,Y, AU - Arai,H, AU - Harada,A, AU - Tomida,M, AU - Takemura,M, AU - Otsuka,R, AU - Ando,F, AU - Shimokata,H, PY - 2020/4/8/entrez PY - 2020/4/8/pubmed PY - 2020/4/21/medline KW - CT KW - DXA KW - Muscle mass KW - gait speed KW - muscle strength SP - 82 EP - 89 JF - The Journal of frailty & aging JO - J Frailty Aging VL - 9 IS - 2 N2 - BACKGROUND: Muscle mass is often mentioned not to reflect muscle strength. For muscle mass assessment skeletal muscle index (SMI) is often used. We have reported that dual-energy X-ray absorptiometry (DXA)-derived SMI does not change with age in women, whereas the cross-sectional muscle area (CSMA) derived from computed tomography (CT) does. OBJECTIVES: The present study aimed to compare CT and DXA for the assessment of muscle tissue. DESIGN AND SETTING: Cross-sectional study in the local residents. PARTICIPANTS: A total of 1818 subjects (age 40-89 years) randomly selected from community dwellers underwent CT examination of the right mid-thigh to measure the cross-sectional muscle area (CSMA). Skeletal muscle mass (SMM) was measured by DXA. The subjects performed physical function tests such as grip strength, knee extension strength, leg extension strength, and gait speed. The correlation between CT-derived CSMA and DXA-derived SMM along with their association with physical function was examined. RESULTS: After controlling for related factors, the partial correlation coefficient of muscle cross-sectional area (CSA) with physical function was larger than that of DXA-derived SMM for gait speed in men (p=0.002) and knee extension strength in women (p=0.03). The partial correlation coefficient of quadriceps (Qc) CSA with physical function was larger than that of DXA-derived SMM for leg extension power in both sexes (p=0.01), gait speed in men (p<0.001), and knee extension strength in women (p<0.001). CONCLUSION: Mid-thigh CT-derived CSMA, especially Qc CSA, showed significant associations with grip strength, knee extension strength, and leg extension power, which were equal to or stronger than those of DXA-derived SMM in community-dwelling middle-aged and older Japanese people. The mid-thigh CSMA may be a predictor of mobility disability, and is considered to be useful in the diagnosis of sarcopenia. SN - 2260-1341 UR - https://www.unboundmedicine.com/medline/citation/32259181/Association_of_Muscle_Strength_and_Gait_Speed_with_Cross_Sectional_Muscle_Area_Determined_by_Mid_Thigh_Computed_Tomography___A_Comparison_with_Skeletal_Muscle_Mass_Measured_by_Dual_Energy_X_Ray_Absorptiometry_ L2 - https://doi.org/10.14283/jfa.2020.16 DB - PRIME DP - Unbound Medicine ER -