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Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease.
Br J Ophthalmol. 2020 06; 104(6):748-751.BJ

Abstract

PURPOSE

To report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).

PARTICIPANT AND METHODS

A 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.

RESULTS

Slit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.

CONCLUSION

SARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva.

Authors+Show Affiliations

Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China zhang-guoming@163.com.Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32265202

Citation

Chen, Lu, et al. "Ocular Manifestations of a Hospitalised Patient With Confirmed 2019 Novel Coronavirus Disease." The British Journal of Ophthalmology, vol. 104, no. 6, 2020, pp. 748-751.
Chen L, Liu M, Zhang Z, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;104(6):748-751.
Chen, L., Liu, M., Zhang, Z., Qiao, K., Huang, T., Chen, M., Xin, N., Huang, Z., Liu, L., Zhang, G., & Wang, J. (2020). Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. The British Journal of Ophthalmology, 104(6), 748-751. https://doi.org/10.1136/bjophthalmol-2020-316304
Chen L, et al. Ocular Manifestations of a Hospitalised Patient With Confirmed 2019 Novel Coronavirus Disease. Br J Ophthalmol. 2020;104(6):748-751. PubMed PMID: 32265202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. AU - Chen,Lu, AU - Liu,Meizhou, AU - Zhang,Zheng, AU - Qiao,Kun, AU - Huang,Ting, AU - Chen,Miaohong, AU - Xin,Na, AU - Huang,Zuliang, AU - Liu,Lei, AU - Zhang,Guoming, AU - Wang,Jiantao, Y1 - 2020/04/07/ PY - 2020/03/16/received PY - 2020/03/25/revised PY - 2020/03/26/accepted PY - 2020/4/9/pubmed PY - 2020/6/23/medline PY - 2020/4/9/entrez KW - conjunctiva KW - infection SP - 748 EP - 751 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 104 IS - 6 N2 - PURPOSE: To report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19). PARTICIPANT AND METHODS: A 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated. RESULTS: Slit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2. CONCLUSION: SARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/32265202/Ocular_manifestations_of_a_hospitalised_patient_with_confirmed_2019_novel_coronavirus_disease_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=32265202 DB - PRIME DP - Unbound Medicine ER -