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Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms.

Abstract

Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32265832

Citation

Zhou, He, et al. "Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms." Frontiers in Endocrinology, vol. 11, 2020, p. 125.
Zhou H, Sun L, Zhang S, et al. Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. Front Endocrinol (Lausanne). 2020;11:125.
Zhou, H., Sun, L., Zhang, S., Zhao, X., Gang, X., & Wang, G. (2020). Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. Frontiers in Endocrinology, 11, 125. https://doi.org/10.3389/fendo.2020.00125
Zhou H, et al. Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. Front Endocrinol (Lausanne). 2020;11:125. PubMed PMID: 32265832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. AU - Zhou,He, AU - Sun,Lin, AU - Zhang,Siwen, AU - Zhao,Xue, AU - Gang,Xiaokun, AU - Wang,Guixia, Y1 - 2020/03/24/ PY - 2019/09/13/received PY - 2020/02/25/accepted PY - 2020/4/9/entrez PY - 2020/4/9/pubmed PY - 2021/2/27/medline KW - causality KW - dysbiosis KW - gut microbiota KW - mechanisms KW - type 1 diabetes SP - 125 EP - 125 JF - Frontiers in endocrinology JO - Front Endocrinol (Lausanne) VL - 11 N2 - Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D. SN - 1664-2392 UR - https://www.unboundmedicine.com/medline/citation/32265832/Evaluating_the_Causal_Role_of_Gut_Microbiota_in_Type_1_Diabetes_and_Its_Possible_Pathogenic_Mechanisms_ L2 - https://doi.org/10.3389/fendo.2020.00125 DB - PRIME DP - Unbound Medicine ER -