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A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT.
Jpn J Radiol. 2020 May; 38(5):409-410.JJ

Abstract

The definite diagnosis of corona virus disease 2019 (COVID-19) is based on the viral isolation or positive result of polymerase chain reaction (PCR) from sputum, or nasal swab, or throat swab. However, the sensitivity to detect COVID-19 of real time (RT)-PCR is reported to be lower than that of chest CT. We report a case of 34-year-old man who was diagnosed as negative for COVID-19 based on the four sequential RT-PCR tests of his pharyngeal swab. Chest CT showed patchy ground-glass opacity on admission, and it rapidly progressed to segmental mixed consolidation and ground-glass opacity 3 days after admission, and it resolved in left upper lobe, but showed multifocal ground-glass opacities 7 days after admission, and they resolved within 2 weeks. The fifth RT-PCR test finally revealed positive results at the fifth day after admission. It is difficult to distinguish COVID-19 pneumonia from other viral pneumonia on CT findings alone; however, we emphasize the utility of chest CT to detect early change of COVID-19 in cases which RT-PCR tests show negative results.

Authors+Show Affiliations

Department of Radiology, Zigong First People's Hospital, Zigong, 643000, People's Republic of China. Zigong Infectious Disease Hospital, Zigong, 643000, People's Republic of China.Department of Radiology, Zigong First People's Hospital, Zigong, 643000, People's Republic of China. Zigong Infectious Disease Hospital, Zigong, 643000, People's Republic of China.Department of Radiology, Zigong First People's Hospital, Zigong, 643000, People's Republic of China. Zigong Infectious Disease Hospital, Zigong, 643000, People's Republic of China.Department of Radiology, Zigong First People's Hospital, Zigong, 643000, People's Republic of China. zhongjianquan.2010@qq.com. Zigong Infectious Disease Hospital, Zigong, 643000, People's Republic of China. zhongjianquan.2010@qq.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32266524

Citation

Feng, Hao, et al. "A Case Report of COVID-19 With False Negative RT-PCR Test: Necessity of Chest CT." Japanese Journal of Radiology, vol. 38, no. 5, 2020, pp. 409-410.
Feng H, Liu Y, Lv M, et al. A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT. Jpn J Radiol. 2020;38(5):409-410.
Feng, H., Liu, Y., Lv, M., & Zhong, J. (2020). A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT. Japanese Journal of Radiology, 38(5), 409-410. https://doi.org/10.1007/s11604-020-00967-9
Feng H, et al. A Case Report of COVID-19 With False Negative RT-PCR Test: Necessity of Chest CT. Jpn J Radiol. 2020;38(5):409-410. PubMed PMID: 32266524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT. AU - Feng,Hao, AU - Liu,Yujian, AU - Lv,Minli, AU - Zhong,Jianquan, Y1 - 2020/04/07/ PY - 2020/02/23/received PY - 2020/03/28/accepted PY - 2020/4/9/pubmed PY - 2020/5/1/medline PY - 2020/4/9/entrez KW - COVID-19, 2019 corona virus disease KW - CT, computed tomography KW - CXR, chest radiography KW - RT-PCR, real-time fluorescence polymerase chain reaction SP - 409 EP - 410 JF - Japanese journal of radiology JO - Jpn J Radiol VL - 38 IS - 5 N2 - The definite diagnosis of corona virus disease 2019 (COVID-19) is based on the viral isolation or positive result of polymerase chain reaction (PCR) from sputum, or nasal swab, or throat swab. However, the sensitivity to detect COVID-19 of real time (RT)-PCR is reported to be lower than that of chest CT. We report a case of 34-year-old man who was diagnosed as negative for COVID-19 based on the four sequential RT-PCR tests of his pharyngeal swab. Chest CT showed patchy ground-glass opacity on admission, and it rapidly progressed to segmental mixed consolidation and ground-glass opacity 3 days after admission, and it resolved in left upper lobe, but showed multifocal ground-glass opacities 7 days after admission, and they resolved within 2 weeks. The fifth RT-PCR test finally revealed positive results at the fifth day after admission. It is difficult to distinguish COVID-19 pneumonia from other viral pneumonia on CT findings alone; however, we emphasize the utility of chest CT to detect early change of COVID-19 in cases which RT-PCR tests show negative results. SN - 1867-108X UR - https://www.unboundmedicine.com/medline/citation/32266524/A_case_report_of_COVID_19_with_false_negative_RT_PCR_test:_necessity_of_chest_CT_ L2 - https://dx.doi.org/10.1007/s11604-020-00967-9 DB - PRIME DP - Unbound Medicine ER -