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Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2.
Science. 2020 05 29; 368(6494):1016-1020.Sci

Abstract

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control.

Authors+Show Affiliations

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, People's Republic of China.National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, People's Republic of China.National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China.National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China. buzhigao@caas.cn chenhualan@caas.cn wugz@ivdc.chinacdc.cn.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China. buzhigao@caas.cn chenhualan@caas.cn wugz@ivdc.chinacdc.cn.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China. buzhigao@caas.cn chenhualan@caas.cn wugz@ivdc.chinacdc.cn. National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32269068

Citation

Shi, Jianzhong, et al. "Susceptibility of Ferrets, Cats, Dogs, and Other Domesticated Animals to SARS-coronavirus 2." Science (New York, N.Y.), vol. 368, no. 6494, 2020, pp. 1016-1020.
Shi J, Wen Z, Zhong G, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2. Science. 2020;368(6494):1016-1020.
Shi, J., Wen, Z., Zhong, G., Yang, H., Wang, C., Huang, B., Liu, R., He, X., Shuai, L., Sun, Z., Zhao, Y., Liu, P., Liang, L., Cui, P., Wang, J., Zhang, X., Guan, Y., Tan, W., Wu, G., ... Bu, Z. (2020). Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2. Science (New York, N.Y.), 368(6494), 1016-1020. https://doi.org/10.1126/science.abb7015
Shi J, et al. Susceptibility of Ferrets, Cats, Dogs, and Other Domesticated Animals to SARS-coronavirus 2. Science. 2020 05 29;368(6494):1016-1020. PubMed PMID: 32269068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2. AU - Shi,Jianzhong, AU - Wen,Zhiyuan, AU - Zhong,Gongxun, AU - Yang,Huanliang, AU - Wang,Chong, AU - Huang,Baoying, AU - Liu,Renqiang, AU - He,Xijun, AU - Shuai,Lei, AU - Sun,Ziruo, AU - Zhao,Yubo, AU - Liu,Peipei, AU - Liang,Libin, AU - Cui,Pengfei, AU - Wang,Jinliang, AU - Zhang,Xianfeng, AU - Guan,Yuntao, AU - Tan,Wenjie, AU - Wu,Guizhen, AU - Chen,Hualan, AU - Bu,Zhigao, Y1 - 2020/04/08/ PY - 2020/03/12/received PY - 2020/04/07/accepted PY - 2020/4/10/pubmed PY - 2020/6/3/medline PY - 2020/4/10/entrez SP - 1016 EP - 1020 JF - Science (New York, N.Y.) JO - Science VL - 368 IS - 6494 N2 - Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/32269068/full_citation L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=32269068 DB - PRIME DP - Unbound Medicine ER -