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Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature.
Head Neck Pathol. 2020 Apr 08 [Online ahead of print]HN

Abstract

Plexiform schwannoma represents an unusual schwannoma variant, characterized by multinodular growth grossly and/or microscopically. A review of the English-language literature reveals only 28 previously reported cases involving the oral cavity, and herein we present 8 additional cases. Among these 36 patients, the average age at diagnosis was 28 years (range 5 to 62 years), with a female-to-male ratio of 1.4:1. The most frequently involved sites were the tongue (n = 13) and lip (n = 11). Lesion duration prior to presentation averaged 5.3 years (range, 6 weeks to 26 years). The average lesion size was 2.1 cm (range, 0.3 to 16 cm). The typical clinical presentation was a painless mass, although infrequent findings included pain/discomfort, paresthesia, difficulty chewing, and limited buccal mobility. All cases clinically appeared as a solitary mass or localized cluster of tumor nodules, with the exception of one patient who had neurofibromatosis 2 (NF2) and exhibited two distinct nodules on the tongue and buccal mucosa. In addition, extraoral neural neoplasms were evident in four patients, including three with NF2. Typical microscopic findings included multiple well-circumscribed tumor nodules, each surrounded by a perineurium-derived capsule with immunoreactivity for epithelial membrane antigen. The nodules contained characteristically bland and diffusely S-100-positive spindle cells arranged in Antoni A and B patterns; however, modest nuclear pleomorphism was evident in three cases. Most patients (n = 23) were treated by excision or enucleation and curettage, and three patients experienced recurrence. Unlike plexiform neurofibromas, plexiform schwannomas exhibit only a weak association with neurofibromatosis and have no known malignant potential.

Authors+Show Affiliations

Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Ave., MSC 507, Charleston, SC, 29425, USA. chi@musc.edu.Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Ave., MSC 507, Charleston, SC, 29425, USA.Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32270393

Citation

Chi, Angela C., et al. "Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature." Head and Neck Pathology, 2020.
Chi AC, Neville BW, Cheng L. Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature. Head Neck Pathol. 2020.
Chi, A. C., Neville, B. W., & Cheng, L. (2020). Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature. Head and Neck Pathology. https://doi.org/10.1007/s12105-020-01159-7
Chi AC, Neville BW, Cheng L. Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature. Head Neck Pathol. 2020 Apr 8; PubMed PMID: 32270393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature. AU - Chi,Angela C, AU - Neville,Brad W, AU - Cheng,Lisa, Y1 - 2020/04/08/ PY - 2020/02/26/received PY - 2020/03/30/accepted PY - 2020/03/27/revised PY - 2020/4/10/entrez KW - Local neoplasm recurrence KW - Mouth mucosa KW - Neurilemmoma KW - Neurofibromatosis 2 KW - Peripheral nerves KW - Schwannoma JF - Head and neck pathology JO - Head Neck Pathol N2 - Plexiform schwannoma represents an unusual schwannoma variant, characterized by multinodular growth grossly and/or microscopically. A review of the English-language literature reveals only 28 previously reported cases involving the oral cavity, and herein we present 8 additional cases. Among these 36 patients, the average age at diagnosis was 28 years (range 5 to 62 years), with a female-to-male ratio of 1.4:1. The most frequently involved sites were the tongue (n = 13) and lip (n = 11). Lesion duration prior to presentation averaged 5.3 years (range, 6 weeks to 26 years). The average lesion size was 2.1 cm (range, 0.3 to 16 cm). The typical clinical presentation was a painless mass, although infrequent findings included pain/discomfort, paresthesia, difficulty chewing, and limited buccal mobility. All cases clinically appeared as a solitary mass or localized cluster of tumor nodules, with the exception of one patient who had neurofibromatosis 2 (NF2) and exhibited two distinct nodules on the tongue and buccal mucosa. In addition, extraoral neural neoplasms were evident in four patients, including three with NF2. Typical microscopic findings included multiple well-circumscribed tumor nodules, each surrounded by a perineurium-derived capsule with immunoreactivity for epithelial membrane antigen. The nodules contained characteristically bland and diffusely S-100-positive spindle cells arranged in Antoni A and B patterns; however, modest nuclear pleomorphism was evident in three cases. Most patients (n = 23) were treated by excision or enucleation and curettage, and three patients experienced recurrence. Unlike plexiform neurofibromas, plexiform schwannomas exhibit only a weak association with neurofibromatosis and have no known malignant potential. SN - 1936-0568 UR - https://www.unboundmedicine.com/medline/citation/32270393/Plexiform_Schwannoma_of_the_Oral_Cavity:_Report_of_Eight_Cases_and_a_Review_of_the_Literature L2 - https://dx.doi.org/10.1007/s12105-020-01159-7 DB - PRIME DP - Unbound Medicine ER -
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