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EncephalApp Stroop App predicts poor sleep quality in patients with minimal hepatic encephalopathy due to hepatitis B-induced liver cirrhosis.
Saudi J Gastroenterol. 2020 May-Jun; 26(3):120-128.SJ

Abstract

Background/Aim

A novel computerised Stroop test- EncephalApp Stroop App (EncephalApp) has good diagnostic validity for minimal hepatic encephalopathy (MHE) in cirrhotic patients. The Stroop test is correlated with sleep disturbances which are common, and severely affects health-related quality of life in cirrhotic patients with MHE. We evaluated the relationship between sleep quality and EncephalApp results in patients with MHE due to hepatitis B-induced liver cirrhosis.

Patients and Methods

We enrolled 180 adult patients with hepatitis B-induced cirrhosis. All patients were tested using the psychometric hepatic encephalopathy score (PHES) and EncephalApp. We analysed the diagnostic validity of EncephalApp for MHE using PHES as the gold standard for reference. The sleep quality of included patients was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The predictive factors for poor sleep quality were analysed using backwards conditional stepwise logistic regression analysis.

Results

Ninety-eight patients (54.4%) were diagnosed with MHE by PHES. Receiver operating characteristic (ROC) curve analysis showed that the threshold value of EncephalApp for MHE diagnosis was 225.60 s. EncephalApp showed 85.2% sensitivity and 77.3% specificity for diagnosing MHE; the area under the ROC curve was 0.864. PSQI scores of cirrhotic patients with MHE were significantly lower than those without MHE (P < 0.05). Child Turcotte Pugh grades (Odds ratio [OR] = 2.11 [1.55-2.85], P < 0.01) and the total Off-time plus On-time of EncephalApp (OR = 4.14 [1.95-6.29], P < 0.01) were independent predictors of poor sleep quality in MHE patients.

Conclusions

The total Off-time plus On-time of EncephalApp predicts poor sleep quality in patients with MHE due to hepatitis B-induced cirrhosis.

Authors+Show Affiliations

Department of Gastroenterology, Ningxia People's Hospital, 301 Zhengyuan North Street, Jinfeng District, Yinchuan, Ningxia, PR China.Department of Gastroenterology, Ningxia People's Hospital, 301 Zhengyuan North Street, Jinfeng District, Yinchuan, Ningxia, PR China.Department of Gastroenterology, Ningxia People's Hospital, 301 Zhengyuan North Street, Jinfeng District, Yinchuan, Ningxia, PR China.Department of Gastroenterology, Ningxia People's Hospital, 301 Zhengyuan North Street, Jinfeng District, Yinchuan, Ningxia, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32270775

Citation

Luo, Ming, et al. "EncephalApp Stroop App Predicts Poor Sleep Quality in Patients With Minimal Hepatic Encephalopathy Due to Hepatitis B-induced Liver Cirrhosis." Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, vol. 26, no. 3, 2020, pp. 120-128.
Luo M, Yu XB, Hu SJ, et al. EncephalApp Stroop App predicts poor sleep quality in patients with minimal hepatic encephalopathy due to hepatitis B-induced liver cirrhosis. Saudi J Gastroenterol. 2020;26(3):120-128.
Luo, M., Yu, X. B., Hu, S. J., & Bai, F. H. (2020). EncephalApp Stroop App predicts poor sleep quality in patients with minimal hepatic encephalopathy due to hepatitis B-induced liver cirrhosis. Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 26(3), 120-128. https://doi.org/10.4103/sjg.SJG_558_19
Luo M, et al. EncephalApp Stroop App Predicts Poor Sleep Quality in Patients With Minimal Hepatic Encephalopathy Due to Hepatitis B-induced Liver Cirrhosis. Saudi J Gastroenterol. 2020 May-Jun;26(3):120-128. PubMed PMID: 32270775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EncephalApp Stroop App predicts poor sleep quality in patients with minimal hepatic encephalopathy due to hepatitis B-induced liver cirrhosis. AU - Luo,Ming, AU - Yu,Xiao-Bing, AU - Hu,Sheng-Juan, AU - Bai,Fei-Hu, PY - 2020/4/10/pubmed PY - 2021/2/20/medline PY - 2020/4/10/entrez KW - EncephalApp Stroop App KW - Stroop test KW - minimal hepatic encephalopathy KW - sleep quality SP - 120 EP - 128 JF - Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association JO - Saudi J Gastroenterol VL - 26 IS - 3 N2 - Background/Aim: A novel computerised Stroop test- EncephalApp Stroop App (EncephalApp) has good diagnostic validity for minimal hepatic encephalopathy (MHE) in cirrhotic patients. The Stroop test is correlated with sleep disturbances which are common, and severely affects health-related quality of life in cirrhotic patients with MHE. We evaluated the relationship between sleep quality and EncephalApp results in patients with MHE due to hepatitis B-induced liver cirrhosis. Patients and Methods: We enrolled 180 adult patients with hepatitis B-induced cirrhosis. All patients were tested using the psychometric hepatic encephalopathy score (PHES) and EncephalApp. We analysed the diagnostic validity of EncephalApp for MHE using PHES as the gold standard for reference. The sleep quality of included patients was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The predictive factors for poor sleep quality were analysed using backwards conditional stepwise logistic regression analysis. Results: Ninety-eight patients (54.4%) were diagnosed with MHE by PHES. Receiver operating characteristic (ROC) curve analysis showed that the threshold value of EncephalApp for MHE diagnosis was 225.60 s. EncephalApp showed 85.2% sensitivity and 77.3% specificity for diagnosing MHE; the area under the ROC curve was 0.864. PSQI scores of cirrhotic patients with MHE were significantly lower than those without MHE (P < 0.05). Child Turcotte Pugh grades (Odds ratio [OR] = 2.11 [1.55-2.85], P < 0.01) and the total Off-time plus On-time of EncephalApp (OR = 4.14 [1.95-6.29], P < 0.01) were independent predictors of poor sleep quality in MHE patients. Conclusions: The total Off-time plus On-time of EncephalApp predicts poor sleep quality in patients with MHE due to hepatitis B-induced cirrhosis. SN - 1998-4049 UR - https://www.unboundmedicine.com/medline/citation/32270775/EncephalApp_Stroop_App_predicts_poor_sleep_quality_in_patients_with_minimal_hepatic_encephalopathy_due_to_hepatitis_B_induced_liver_cirrhosis_ L2 - http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2020;volume=26;issue=3;spage=120;epage=128;aulast=Luo DB - PRIME DP - Unbound Medicine ER -