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Delivery in pregnant women infected with SARS-CoV-2: A fast review.
Int J Gynaecol Obstet. 2020 Jul; 150(1):41-46.IJ

Abstract

BACKGROUND

Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered.

OBJECTIVE

To review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS-CoV-2.

SEARCH STRATEGY

Combination of the following key words: COVID-19, SARS-CoV-2, and pregnancy in Embase and PubMed databases.

SELECTION CRITERIA

Papers reporting cases of women infected with SARS-CoV-2 who delivered.

DATA COLLECTION AND ANALYSIS

The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes.

MAIN RESULTS

In the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI, 3.5-19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI, 35.8-61.3). Two newborns testing positive for SARS-CoV-2 by real-time RT-PCR assay were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated but the RT-PCR test was negative.

CONCLUSIONS

The rate of vertical or peripartum transmission of SARS-CoV-2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.Verona University Hospital, Verona, Italy.Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.Department of Obstetrics and Gynecology, AOUI Verona, Verona, Italy.Department of Obstetrics and Gynecology, Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32271947

Citation

Parazzini, Fabio, et al. "Delivery in Pregnant Women Infected With SARS-CoV-2: a Fast Review." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 150, no. 1, 2020, pp. 41-46.
Parazzini F, Bortolus R, Mauri PA, et al. Delivery in pregnant women infected with SARS-CoV-2: A fast review. Int J Gynaecol Obstet. 2020;150(1):41-46.
Parazzini, F., Bortolus, R., Mauri, P. A., Favilli, A., Gerli, S., & Ferrazzi, E. (2020). Delivery in pregnant women infected with SARS-CoV-2: A fast review. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 150(1), 41-46. https://doi.org/10.1002/ijgo.13166
Parazzini F, et al. Delivery in Pregnant Women Infected With SARS-CoV-2: a Fast Review. Int J Gynaecol Obstet. 2020;150(1):41-46. PubMed PMID: 32271947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delivery in pregnant women infected with SARS-CoV-2: A fast review. AU - Parazzini,Fabio, AU - Bortolus,Renata, AU - Mauri,Paola Agnese, AU - Favilli,Alessandro, AU - Gerli,Sandro, AU - Ferrazzi,Enrico, Y1 - 2020/05/01/ PY - 2020/04/03/received PY - 2020/04/04/revised PY - 2020/04/08/accepted PY - 2020/4/10/pubmed PY - 2020/6/24/medline PY - 2020/4/10/entrez KW - COVID-19 KW - Cesarean delivery KW - Neonatal outcome KW - Pregnancy KW - Review KW - SARS-CoV-2 KW - Vaginal delivery KW - Vertical transmission SP - 41 EP - 46 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 150 IS - 1 N2 - BACKGROUND: Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered. OBJECTIVE: To review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS-CoV-2. SEARCH STRATEGY: Combination of the following key words: COVID-19, SARS-CoV-2, and pregnancy in Embase and PubMed databases. SELECTION CRITERIA: Papers reporting cases of women infected with SARS-CoV-2 who delivered. DATA COLLECTION AND ANALYSIS: The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. MAIN RESULTS: In the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI, 3.5-19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI, 35.8-61.3). Two newborns testing positive for SARS-CoV-2 by real-time RT-PCR assay were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated but the RT-PCR test was negative. CONCLUSIONS: The rate of vertical or peripartum transmission of SARS-CoV-2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring. SN - 1879-3479 UR - https://www.unboundmedicine.com/medline/citation/32271947/Delivery_in_pregnant_women_infected_with_SARS_CoV_2:_A_fast_review_ L2 - https://doi.org/10.1002/ijgo.13166 DB - PRIME DP - Unbound Medicine ER -