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Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.
J Thromb Haemost. 2020 Jun; 18(6):1421-1424.JT

Abstract

BACKGROUND

Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned.

OBJECTIVES

To determine the incidence of VTE in patients with severe NCP.

METHODS

In this study, 81 severe NCP patients in the intensive care unit (ICU) of Union Hospital (Wuhan, China) were enrolled. The results of conventional coagulation parameters and lower limb vein ultrasonography of these patients were retrospectively collected and analyzed.

RESULTS

The incidence of VTE in these patients was 25% (20/81), of which 8 patients with VTE events died. The VTE group was different from the non-VTE group in age, lymphocyte counts, activated partial thromboplastin time (APTT), D-dimer, etc. If 1.5 µg/mL was used as the D-dimer cut-off value to predicting VTE, the sensitivity was 85.0%, the specificity was 88.5%, and the negative predictive value (NPV) was 94.7%.

CONCLUSIONS

The incidence of VTE in patients with severe NCP is 25% (20/81), which may be related to poor prognosis. The significant increase of D-dimer in severe NCP patients is a good index for identifying high-risk groups of VTE.

Authors+Show Affiliations

Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Beijing Institute of Respiratory Medicine, Beijing, China. Beijing Engineering Research Center for Diagnosis and Treatment of Respiratory and Critical Care Medicine (Beijing Chao-Yang Hospital), Beijing, China. Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32271988

Citation

Cui, Songping, et al. "Prevalence of Venous Thromboembolism in Patients With Severe Novel Coronavirus Pneumonia." Journal of Thrombosis and Haemostasis : JTH, vol. 18, no. 6, 2020, pp. 1421-1424.
Cui S, Chen S, Li X, et al. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421-1424.
Cui, S., Chen, S., Li, X., Liu, S., & Wang, F. (2020). Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis : JTH, 18(6), 1421-1424. https://doi.org/10.1111/jth.14830
Cui S, et al. Prevalence of Venous Thromboembolism in Patients With Severe Novel Coronavirus Pneumonia. J Thromb Haemost. 2020;18(6):1421-1424. PubMed PMID: 32271988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. AU - Cui,Songping, AU - Chen,Shuo, AU - Li,Xiunan, AU - Liu,Shi, AU - Wang,Feng, Y1 - 2020/05/06/ PY - 2020/04/03/received PY - 2020/04/04/accepted PY - 2020/4/10/pubmed PY - 2020/6/11/medline PY - 2020/4/10/entrez KW - D-dimer KW - blood coagulation KW - coagulation parameter KW - novel coronavirus pneumonia KW - venous thromboembolism SP - 1421 EP - 1424 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 18 IS - 6 N2 - BACKGROUND: Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned. OBJECTIVES: To determine the incidence of VTE in patients with severe NCP. METHODS: In this study, 81 severe NCP patients in the intensive care unit (ICU) of Union Hospital (Wuhan, China) were enrolled. The results of conventional coagulation parameters and lower limb vein ultrasonography of these patients were retrospectively collected and analyzed. RESULTS: The incidence of VTE in these patients was 25% (20/81), of which 8 patients with VTE events died. The VTE group was different from the non-VTE group in age, lymphocyte counts, activated partial thromboplastin time (APTT), D-dimer, etc. If 1.5 µg/mL was used as the D-dimer cut-off value to predicting VTE, the sensitivity was 85.0%, the specificity was 88.5%, and the negative predictive value (NPV) was 94.7%. CONCLUSIONS: The incidence of VTE in patients with severe NCP is 25% (20/81), which may be related to poor prognosis. The significant increase of D-dimer in severe NCP patients is a good index for identifying high-risk groups of VTE. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/32271988/Prevalence_of_venous_thromboembolism_in_patients_with_severe_novel_coronavirus_pneumonia_ L2 - https://doi.org/10.1111/jth.14830 DB - PRIME DP - Unbound Medicine ER -