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High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation.
Obesity (Silver Spring). 2020 07; 28(7):1195-1199.O

Abstract

OBJECTIVE

The COVID-19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has not been fully documented.

METHODS

This retrospective cohort study analyzed the relationship between clinical characteristics, including BMI, and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS-CoV-2 in a single French center.

RESULTS

Obesity (BMI > 30) and severe obesity (BMI > 35) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories (P < 0.01, χ2 test for trend), and it was greatest in patients with BMI > 35 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex (P < 0.05) and BMI (P < 0.05), independent of age, diabetes, and hypertension. The odds ratio for IMV in patients with BMI > 35 versus patients with BMI < 25 was 7.36 (1.63-33.14; P = 0.02).

CONCLUSIONS

The present study showed a high frequency of obesity among patients admitted in intensive care for SARS-CoV-2. Disease severity increased with BMI. Obesity is a risk factor for SARS-CoV-2 severity, requiring increased attention to preventive measures in susceptible individuals.

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Authors+Show Affiliations

Simonnet A
Department of Intensive Care, Centre Hospitalier Universitaire Lille, Lille, France.
Chetboun M
University of Lille, Inserm, Centre Hospitalier Universitaire Lille, Lille Pasteur Institute, U1190, European Genomic Institute for Diabetes, Lille, France.
Poissy J
Department of Intensive Care, Centre Hospitalier Universitaire Lille, Lille, France.
Raverdy V
University of Lille, Inserm, Centre Hospitalier Universitaire Lille, Lille Pasteur Institute, U1190, European Genomic Institute for Diabetes, Lille, France.
Noulette J
University of Lille, Inserm, Centre Hospitalier Universitaire Lille, Lille Pasteur Institute, U1190, European Genomic Institute for Diabetes, Lille, France.
Duhamel A
Centre Hospitalier Universitaire Lille, U2694 METRICS, University of Lille, Lille, France.
Labreuche J
Centre Hospitalier Universitaire Lille, U2694 METRICS, University of Lille, Lille, France.
Mathieu D
Department of Intensive Care, Centre Hospitalier Universitaire Lille, Lille, France.
Pattou F
University of Lille, Inserm, Centre Hospitalier Universitaire Lille, Lille Pasteur Institute, U1190, European Genomic Institute for Diabetes, Lille, France. Integrated Center for Obesity, Centre Hospitalier Universitaire Lille, Lille, France.
Jourdain M
Department of Intensive Care, Centre Hospitalier Universitaire Lille, Lille, France. University of Lille, Inserm, Centre Hospitalier Universitaire Lille, Lille Pasteur Institute, U1190, European Genomic Institute for Diabetes, Lille, France.
LICORN and the Lille COVID-19 and Obesity study group
No affiliation info available

MeSH

AdultAgedBetacoronavirusBody Mass IndexCOVID-19Coronavirus InfectionsFemaleFranceHospitalizationHumansMaleMiddle AgedObesityPandemicsPneumonia, ViralPrevalenceRespiration, ArtificialRetrospective StudiesRisk FactorsSARS-CoV-2Young Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32271993

Clinical Trial Links

Association of Comorbidities With COVID19
Comorbidities and Risk Score in COVID-19 Patients

Citation

Simonnet, Arthur, et al. "High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation." Obesity (Silver Spring, Md.), vol. 28, no. 7, 2020, pp. 1195-1199.
Simonnet A, Chetboun M, Poissy J, et al. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity (Silver Spring). 2020;28(7):1195-1199.
Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F., & Jourdain, M. (2020). High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity (Silver Spring, Md.), 28(7), 1195-1199. https://doi.org/10.1002/oby.22831
Simonnet A, et al. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity (Silver Spring). 2020;28(7):1195-1199. PubMed PMID: 32271993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. AU - Simonnet,Arthur, AU - Chetboun,Mikael, AU - Poissy,Julien, AU - Raverdy,Violeta, AU - Noulette,Jerome, AU - Duhamel,Alain, AU - Labreuche,Julien, AU - Mathieu,Daniel, AU - Pattou,Francois, AU - Jourdain,Merce, AU - ,, Y1 - 2020/06/10/ PY - 2020/04/08/received PY - 2020/04/08/revised PY - 2020/04/08/accepted PY - 2020/4/10/pubmed PY - 2020/7/7/medline PY - 2020/4/10/entrez SP - 1195 EP - 1199 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 28 IS - 7 N2 - OBJECTIVE: The COVID-19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has not been fully documented. METHODS: This retrospective cohort study analyzed the relationship between clinical characteristics, including BMI, and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS-CoV-2 in a single French center. RESULTS: Obesity (BMI > 30) and severe obesity (BMI > 35) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories (P < 0.01, χ2 test for trend), and it was greatest in patients with BMI > 35 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex (P < 0.05) and BMI (P < 0.05), independent of age, diabetes, and hypertension. The odds ratio for IMV in patients with BMI > 35 versus patients with BMI < 25 was 7.36 (1.63-33.14; P = 0.02). CONCLUSIONS: The present study showed a high frequency of obesity among patients admitted in intensive care for SARS-CoV-2. Disease severity increased with BMI. Obesity is a risk factor for SARS-CoV-2 severity, requiring increased attention to preventive measures in susceptible individuals. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/32271993/full_citation DB - PRIME DP - Unbound Medicine ER -