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Coronavirus membrane fusion mechanism offers a potential target for antiviral development.
Antiviral Res. 2020 06; 178:104792.AR

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses.

Authors+Show Affiliations

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA. Electronic address: sd386@cornell.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32272173

Citation

Tang, Tiffany, et al. "Coronavirus Membrane Fusion Mechanism Offers a Potential Target for Antiviral Development." Antiviral Research, vol. 178, 2020, p. 104792.
Tang T, Bidon M, Jaimes JA, et al. Coronavirus membrane fusion mechanism offers a potential target for antiviral development. Antiviral Res. 2020;178:104792.
Tang, T., Bidon, M., Jaimes, J. A., Whittaker, G. R., & Daniel, S. (2020). Coronavirus membrane fusion mechanism offers a potential target for antiviral development. Antiviral Research, 178, 104792. https://doi.org/10.1016/j.antiviral.2020.104792
Tang T, et al. Coronavirus Membrane Fusion Mechanism Offers a Potential Target for Antiviral Development. Antiviral Res. 2020;178:104792. PubMed PMID: 32272173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus membrane fusion mechanism offers a potential target for antiviral development. AU - Tang,Tiffany, AU - Bidon,Miya, AU - Jaimes,Javier A, AU - Whittaker,Gary R, AU - Daniel,Susan, Y1 - 2020/04/06/ PY - 2020/03/14/received PY - 2020/04/05/revised PY - 2020/04/05/accepted PY - 2020/4/10/pubmed PY - 2020/7/7/medline PY - 2020/4/10/entrez KW - COVID-19 KW - Fusion peptide KW - Middle east respiratory syndrome KW - SARS-CoV-2 KW - Severe acute respiratory syndrome KW - Spike protein SP - 104792 EP - 104792 JF - Antiviral research JO - Antiviral Res. VL - 178 N2 - The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/32272173/Coronavirus_membrane_fusion_mechanism_offers_a_potential_target_for_antiviral_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(20)30206-0 DB - PRIME DP - Unbound Medicine ER -