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Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes.
Life Sci. 2020 Jun 15; 251:117635.LS

Abstract

Molecular structures containing gold, such as auranofin, have been extensively studied in the diagnosis and treatment of many diseases, including cancer treatment. The pharmacological properties of the newly synthesized unique gold-ligand structures have been reported for different cancer cell lines. However, findings on bishydeten-metal salt complexes with gold are rare. In this work, the synthesis of five novel cyanide-bridged coordination compounds having the closed formulae [Ni(bishydeten)][Au(CN)2]2 (1), [Cu(bishydeten)][Au(CN)2]2 (2), [Zn(bishydeten)2Au3(CN)4][Au2(CN)3] (3), [Cd(bishydeten)0,5]2[Au(CN)2]4.2H2O (4), and [Cd(bishydeten)2][Au(CN)2]2 (5) (where bisyhdeten = N,N-bis(2-hydroxyethyl)ethylene diamine), and their characterization by elemental, infrared, ESI-MS, X-ray (for 2) and thermic measurement methods were performed. Complexes 1 and 3 are thermally more stable than the other three complexes. For these, pharmacological adequacies were also tested. The nucleic acid and protein binding affinities of the Au (I) compounds were also estimated by spectroscopic and electrophoretic techniques. Au (I) complexes were identified as strong chemotherapeutic with mild cytotoxicity, and they demonstrated a dose-dependent inhibition on the growth of cancer cells with IC50 at 0.11 to 0.47 μM. Investigation of mechanisms of action on cells revealed that Au (I) compounds managed to inhibit cell migration and led to a decrease in cytoskeletal proteins such as CK7 and CK20. However, Au (I) compounds failed to inhibit DNA topoisomerase I. Overall, and we suggest that potent antiproliferative activity, mild cytotoxicity, good solubility, and micromolar dosage of Au (I) compounds containing bisyhdeten-metal derivatives render them the potential focus of further studies as chemotherapeutic agents.

Authors+Show Affiliations

Department of Chemistry, Faculty of Arts and Science, Yozgat Bozok University, 66200 Yozgat, Turkey. Electronic address: ahmet.karadag@bozok.edu.tr.Department of Basic Medical Science, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.TÜBİTAK, MRC, Genetic Engineering & Biotechnology Institute, 41470 Gebze, Turkey; Faculty of Medicine, Department of Basic Medical Sciences, Medical Biology, University of Health Sciences, 34668 Istanbul, Turkey.Department of Chemistry, Science and Arts Faculty, Tokat Gaziosmanpaşa University, 60240 Tokat, Turkey.Scientific and Technological Research Application and Research Centre, Sinop University, Sinop, Turkey.Sen Research Group, Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey. Electronic address: fatih.sen@dpu.edu.tr.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32272179

Citation

Karadağ, Ahmet, et al. "Synthesis, Characterization and Anticancer Activity in Vitro Evaluation of Novel Dicyanoaurate (I)-based Complexes." Life Sciences, vol. 251, 2020, p. 117635.
Karadağ A, Aydın A, Tekin Ş, et al. Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes. Life Sci. 2020;251:117635.
Karadağ, A., Aydın, A., Tekin, Ş., Akbaş, H., Şahin, O., & Sen, F. (2020). Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes. Life Sciences, 251, 117635. https://doi.org/10.1016/j.lfs.2020.117635
Karadağ A, et al. Synthesis, Characterization and Anticancer Activity in Vitro Evaluation of Novel Dicyanoaurate (I)-based Complexes. Life Sci. 2020 Jun 15;251:117635. PubMed PMID: 32272179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes. AU - Karadağ,Ahmet, AU - Aydın,Ali, AU - Tekin,Şaban, AU - Akbaş,Hüseyin, AU - Şahin,Onur, AU - Sen,Fatih, Y1 - 2020/04/06/ PY - 2020/02/24/received PY - 2020/04/01/revised PY - 2020/04/01/accepted PY - 2020/4/10/pubmed PY - 2020/5/6/medline PY - 2020/4/10/entrez KW - Antiproliferative effect KW - Crystal structure KW - Cytotoxicity KW - Dicyanoaurate (I) KW - Spectroscopic titration SP - 117635 EP - 117635 JF - Life sciences JO - Life Sci. VL - 251 N2 - Molecular structures containing gold, such as auranofin, have been extensively studied in the diagnosis and treatment of many diseases, including cancer treatment. The pharmacological properties of the newly synthesized unique gold-ligand structures have been reported for different cancer cell lines. However, findings on bishydeten-metal salt complexes with gold are rare. In this work, the synthesis of five novel cyanide-bridged coordination compounds having the closed formulae [Ni(bishydeten)][Au(CN)2]2 (1), [Cu(bishydeten)][Au(CN)2]2 (2), [Zn(bishydeten)2Au3(CN)4][Au2(CN)3] (3), [Cd(bishydeten)0,5]2[Au(CN)2]4.2H2O (4), and [Cd(bishydeten)2][Au(CN)2]2 (5) (where bisyhdeten = N,N-bis(2-hydroxyethyl)ethylene diamine), and their characterization by elemental, infrared, ESI-MS, X-ray (for 2) and thermic measurement methods were performed. Complexes 1 and 3 are thermally more stable than the other three complexes. For these, pharmacological adequacies were also tested. The nucleic acid and protein binding affinities of the Au (I) compounds were also estimated by spectroscopic and electrophoretic techniques. Au (I) complexes were identified as strong chemotherapeutic with mild cytotoxicity, and they demonstrated a dose-dependent inhibition on the growth of cancer cells with IC50 at 0.11 to 0.47 μM. Investigation of mechanisms of action on cells revealed that Au (I) compounds managed to inhibit cell migration and led to a decrease in cytoskeletal proteins such as CK7 and CK20. However, Au (I) compounds failed to inhibit DNA topoisomerase I. Overall, and we suggest that potent antiproliferative activity, mild cytotoxicity, good solubility, and micromolar dosage of Au (I) compounds containing bisyhdeten-metal derivatives render them the potential focus of further studies as chemotherapeutic agents. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32272179/Synthesis,_characterization_and_anticancer_activity_in_vitro_evaluation_of_novel_dicyanoaurate_(I)-based_complexes L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)30383-0 DB - PRIME DP - Unbound Medicine ER -