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Renal iodine123-metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction.
Auton Neurosci. 2020 07; 226:102671.AN

Abstract

BACKGROUND

Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine123-metaiodobenzylguanidine (123I-MIBG) scintigraphy is associated with muscle sympathetic nerve activity (MSNA) in patients with hypertension. However, it is unclear whether renal 123I-MIBG scintigraphy is useful for assessment of SNA in HFrEF.

METHODS

The study population consisted of 24 HFrEF patients and 11 healthy subjects as controls. Patients with HFrEF underwent 123I-MIBG scintigraphy and hemodynamics using a Swan-Ganz catheter (SGC). HFrEF was defined as echocardiography with left ventricular ejection fraction (LVEF) < 50%. MSNA was measured from the peroneal nerve for direct evaluation of SNA. Renal 123I-MIBG scintigraphy was performed simultaneously with cardiac scintigraphy. The early and delayed kidney-to-mediastinum ratio (K/M), early and delayed heart-to-mediastinum ratio (H/M), and washout rate (WR) were calculated.

RESULTS

LVEFs were 35% ± 11% in patients with HFrEF and 63% ± 10% in the controls (p < 0.01). The WR of cardiac 123I-MIBG showed no relation to MSNA, but was related to stroke volume (r = 0.45, p < 0.05). In contrast, the WR of renal 123I-MIBG scintigraphy (average of both sides) showed a strong correlation with MSNA (BI, r = 0.70, p < 0.01; BF, r = 0.66, p < 0.01); however, no significant correlations were detected between renal 123I-MIBG scintigraphy and SGC results.

CONCLUSIONS

The WR of renal 123I-MIBG scintigraphy may reflect MSNA. Further studies are needed to clarify the relationship between renal 123I-MIBG imaging and renal SNA.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan. Electronic address: sakurasoma1209@yahoo.co.jp.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Nuclear Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.Departments of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32272358

Citation

Okabe, Yoshitaka, et al. "Renal Iodine123-metaiodobenzylguanidine Scintigraphy Relates to Muscle Sympathetic Nervous Activity in Heart Failure With Reduced Ejection Fraction." Autonomic Neuroscience : Basic & Clinical, vol. 226, 2020, p. 102671.
Okabe Y, Murai H, Tokuhisa H, et al. Renal iodine123-metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction. Auton Neurosci. 2020;226:102671.
Okabe, Y., Murai, H., Tokuhisa, H., Hamaoka, T., Mukai, Y., Sugimoto, H., Takashima, S. I., Kato, T., Matsuo, S., Usui, S., Furusho, H., Takamura, M., & Kaneko, S. (2020). Renal iodine123-metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction. Autonomic Neuroscience : Basic & Clinical, 226, 102671. https://doi.org/10.1016/j.autneu.2020.102671
Okabe Y, et al. Renal Iodine123-metaiodobenzylguanidine Scintigraphy Relates to Muscle Sympathetic Nervous Activity in Heart Failure With Reduced Ejection Fraction. Auton Neurosci. 2020;226:102671. PubMed PMID: 32272358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal iodine123-metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction. AU - Okabe,Yoshitaka, AU - Murai,Hisayoshi, AU - Tokuhisa,Hideki, AU - Hamaoka,Takuto, AU - Mukai,Yusuke, AU - Sugimoto,Hiroyuki, AU - Takashima,Shin-Ichiro, AU - Kato,Takeshi, AU - Matsuo,Shinro, AU - Usui,Soichiro, AU - Furusho,Hiroshi, AU - Takamura,Masayuki, AU - Kaneko,Shuichi, Y1 - 2020/03/31/ PY - 2019/09/18/received PY - 2020/03/29/revised PY - 2020/03/29/accepted PY - 2020/4/10/pubmed PY - 2020/4/10/medline PY - 2020/4/10/entrez KW - HFrEF KW - Iodine(123)-metaiodobenzylguanidine imaging KW - Muscle sympathetic nerve activity SP - 102671 EP - 102671 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 226 N2 - BACKGROUND: Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine123-metaiodobenzylguanidine (123I-MIBG) scintigraphy is associated with muscle sympathetic nerve activity (MSNA) in patients with hypertension. However, it is unclear whether renal 123I-MIBG scintigraphy is useful for assessment of SNA in HFrEF. METHODS: The study population consisted of 24 HFrEF patients and 11 healthy subjects as controls. Patients with HFrEF underwent 123I-MIBG scintigraphy and hemodynamics using a Swan-Ganz catheter (SGC). HFrEF was defined as echocardiography with left ventricular ejection fraction (LVEF) < 50%. MSNA was measured from the peroneal nerve for direct evaluation of SNA. Renal 123I-MIBG scintigraphy was performed simultaneously with cardiac scintigraphy. The early and delayed kidney-to-mediastinum ratio (K/M), early and delayed heart-to-mediastinum ratio (H/M), and washout rate (WR) were calculated. RESULTS: LVEFs were 35% ± 11% in patients with HFrEF and 63% ± 10% in the controls (p < 0.01). The WR of cardiac 123I-MIBG showed no relation to MSNA, but was related to stroke volume (r = 0.45, p < 0.05). In contrast, the WR of renal 123I-MIBG scintigraphy (average of both sides) showed a strong correlation with MSNA (BI, r = 0.70, p < 0.01; BF, r = 0.66, p < 0.01); however, no significant correlations were detected between renal 123I-MIBG scintigraphy and SGC results. CONCLUSIONS: The WR of renal 123I-MIBG scintigraphy may reflect MSNA. Further studies are needed to clarify the relationship between renal 123I-MIBG imaging and renal SNA. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32272358/Renal_iodine123-metaiodobenzylguanidine_scintigraphy_relates_to_muscle_sympathetic_nervous_activity_in_heart_failure_with_reduced_ejection_fraction L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(19)30233-4 DB - PRIME DP - Unbound Medicine ER -
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