TY - JOUR T1 - [Efficacy and mechanism of electroacupuncture on insulin resistant polycystic ovary syndrome]. AU - Yu,Li-Qing, AU - Cao,Lian-Ying, AU - Xie,Jing, AU - Shi,Yin, AU - Zhou,Li-Yan, AU - He,Tian-Feng, AU - Chu,Xiao-Yan, PY - 2020/4/11/entrez PY - 2020/4/11/pubmed PY - 2020/7/29/medline KW - electroacupuncture (EA) KW - insulin resistance (IR) KW - lipid metabolism KW - polycystic ovary syndrome (PCOS) KW - randomized controlled trial (RCT) SP - 379 EP - 83 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 40 IS - 4 N2 - OBJECTIVE: To explore the therapeutic effect and partial mechanism of electroacupuncture (EA) for patients with insulin resistance (IR) polycystic ovary syndrome (PCOS). METHODS: Seventy patients with IR-PCOS were randomly divided into an EA group (36 cases, 5 cases dropped off) and a medication group (34 cases, 4 cases dropped off). The patients in the medication group were treated with oral administration of metformin hydrochloride, 500 mg each time, twice a day. The patients in the EA group were treated with EA (continuous wave, 2 Hz of frequency) at Zusanli (ST 36), Zhongwan (CV 12), Qihai (CV 6), Yishu (EX-B 3), Shenshu (BL 23), Pishu (BL 20), Ciliao (BL 32) for 30 min, three times a week. One menstrual cycle or 4 weeks were taken as a course of treatment, and 3 continuous courses were given. The follow-up was 3 months. The lipid metabolism indexes of triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL), homeostasis model assessment-insulin resistance index (HOMA-IR) and testosterone (T) in serum were compared before and after treatment, and the clinical effects of the two groups were evaluated during the follow-up. RESULTS: The total effective rate was 67.7% (21/31) in the EA group and 60.0% (18/30) in the medication group, with no significant difference between the two groups (P>0.05). After treatment, the levels of serum T, HOMA-IR, LDL, TG and TC were decreased significantly in the two groups (P<0.01, P<0.05), and HDL was increased significantly (P<0.01); the levels of TC in the EA group after treatment was lower than that in the medication group (P<0.05). CONCLUSION: EA may adjust some dyslipidemia in patients to correct IR and improve endocrine disorder of PCOS, which had superior/similar effects to metformin. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/32275366/[Efficacy_and_mechanism_of_electroacupuncture_on_insulin_resistant_polycystic_ovary_syndrome]_ DB - PRIME DP - Unbound Medicine ER -