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Plasma fibrinolytic activity in sickle cell disease.
Trop Geogr Med. 1988 Oct; 40(4):331-3.TG

Abstract

Changes in plasma fibrinolytic activity, as measured by euglobulin lysis time (ELT) and serum fibrinogen degradation products (FDP) were investigated in 70 Nigerians with homozygous (HbSS) sickle cell disease (SCD), (50 in stable state and 20 in crisis state) and 75 age-matched non-sicklers. All had normal hemoglobin genotype (HbAA). The levels of ELT and FDP were significantly higher in sicklers in steady state than non-sicklers, but significantly lowered in sicklers in crisis than both non-sicklers and sicklers in stable state. Disturbances of fibrinolytic mechanism in both steady and crisis state might have a relationship to the clinical state of the individual patient.

Authors+Show Affiliations

Department of Haematology, College of Medical Sciences, University of Benin, Bendel State, Nigeria.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3227553

Citation

Famodu, A A.. "Plasma Fibrinolytic Activity in Sickle Cell Disease." Tropical and Geographical Medicine, vol. 40, no. 4, 1988, pp. 331-3.
Famodu AA. Plasma fibrinolytic activity in sickle cell disease. Trop Geogr Med. 1988;40(4):331-3.
Famodu, A. A. (1988). Plasma fibrinolytic activity in sickle cell disease. Tropical and Geographical Medicine, 40(4), 331-3.
Famodu AA. Plasma Fibrinolytic Activity in Sickle Cell Disease. Trop Geogr Med. 1988;40(4):331-3. PubMed PMID: 3227553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma fibrinolytic activity in sickle cell disease. A1 - Famodu,A A, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 331 EP - 3 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 40 IS - 4 N2 - Changes in plasma fibrinolytic activity, as measured by euglobulin lysis time (ELT) and serum fibrinogen degradation products (FDP) were investigated in 70 Nigerians with homozygous (HbSS) sickle cell disease (SCD), (50 in stable state and 20 in crisis state) and 75 age-matched non-sicklers. All had normal hemoglobin genotype (HbAA). The levels of ELT and FDP were significantly higher in sicklers in steady state than non-sicklers, but significantly lowered in sicklers in crisis than both non-sicklers and sicklers in stable state. Disturbances of fibrinolytic mechanism in both steady and crisis state might have a relationship to the clinical state of the individual patient. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/3227553/Plasma_fibrinolytic_activity_in_sickle_cell_disease_ L2 - http://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -