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Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study.
BMC Oral Health. 2020 Apr 10; 20(1):100.BO

Abstract

BACKGROUND

The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposures over time in older adults. We undertake this study to evaluate the associations of the number of natural teeth and/or denture use with mortality in Chinese elderly.

METHODS

This is a prospective cohort study of 36,283 older adults (median age: 90). The number of natural teeth and denture use were collected with structured questionnaire. We evaluated hazard ratios (HRs) and confidence intervals (CIs) using a Cox proportional hazards model adjusting for demographic factors, education, income, lifestyle factors, and comorbidities.

RESULTS

We documented 25,857 deaths during 145,947 person-years of observation. Compared to those with 20+ teeth, tooth loss was associated with a gradual increase in mortality, with an adjusted HR of 1.14 (95% CI, 1.06 to 1.23) for those with 10-19 teeth, 1.23 (95% CI, 1.15 to 1.31) for those with 1-9 teeth, and 1.35 (95% CI, 1.26 to 1.44) for those without natural teeth. Denture use was associated with lower risk of mortality (adjusted HR 0.81; 95% CI, 0.77 to 0.84). Subgroup analyses indicated that the benefit of denture use was greater in men than in women (P = 0.02) and tended to decrease with age (P < 0.001). The effects of denture use did not differ among various degrees of tooth loss (P = 0.17).

CONCLUSIONS

Tooth loss was associated with an increased risk of mortality in older adults. Denture use provided a protective effect against death for all degrees of tooth loss however, this effect appeared to be modified by sex and age.

Authors+Show Affiliations

Clinical Research Center, The Seventh Affiliated Hospital; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, Guangdong, China.National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing, 100021, China.Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.Nutritional Epidemiology Lab, Pennsylvania State University, Philadelphia, PA, USA.Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing, China.Center for the Study of Aging and Human Development and the Geriatric Division of School of Medicine, Duke University, Durham, North Carolina, USA.Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing, China.Center for the Study of Aging and Human Development and the Geriatric Division of School of Medicine, Duke University, Durham, North Carolina, USA. zengyi@nsd.pku.edu.cn. Center for Study of Healthy Aging and Development Studies, Peking University, Beijing, China. zengyi@nsd.pku.edu.cn.Division of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China. maochen9@smu.edu.cn.National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing, 100021, China. shixm@chinacdc.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32276615

Citation

Yuan, Jin-Qiu, et al. "Number of Natural Teeth, Denture Use and Mortality in Chinese Elderly: a Population-based Prospective Cohort Study." BMC Oral Health, vol. 20, no. 1, 2020, p. 100.
Yuan JQ, Lv YB, Kraus VB, et al. Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study. BMC Oral Health. 2020;20(1):100.
Yuan, J. Q., Lv, Y. B., Kraus, V. B., Gao, X., Yin, Z. X., Chen, H. S., Luo, J. S., Zeng, Y., Mao, C., & Shi, X. M. (2020). Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study. BMC Oral Health, 20(1), 100. https://doi.org/10.1186/s12903-020-01084-9
Yuan JQ, et al. Number of Natural Teeth, Denture Use and Mortality in Chinese Elderly: a Population-based Prospective Cohort Study. BMC Oral Health. 2020 Apr 10;20(1):100. PubMed PMID: 32276615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study. AU - Yuan,Jin-Qiu, AU - Lv,Yue-Bin, AU - Kraus,Virginia Byers, AU - Gao,Xiang, AU - Yin,Zhao-Xue, AU - Chen,Hua-Shuai, AU - Luo,Jie-Si, AU - Zeng,Yi, AU - Mao,Chen, AU - Shi,Xiao-Ming, Y1 - 2020/04/10/ PY - 2019/05/26/received PY - 2020/03/25/accepted PY - 2020/4/12/entrez PY - 2020/4/12/pubmed PY - 2020/4/12/medline KW - Cohort study KW - Denture KW - Mortality KW - Tooth loss SP - 100 EP - 100 JF - BMC oral health JO - BMC Oral Health VL - 20 IS - 1 N2 - BACKGROUND: The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposures over time in older adults. We undertake this study to evaluate the associations of the number of natural teeth and/or denture use with mortality in Chinese elderly. METHODS: This is a prospective cohort study of 36,283 older adults (median age: 90). The number of natural teeth and denture use were collected with structured questionnaire. We evaluated hazard ratios (HRs) and confidence intervals (CIs) using a Cox proportional hazards model adjusting for demographic factors, education, income, lifestyle factors, and comorbidities. RESULTS: We documented 25,857 deaths during 145,947 person-years of observation. Compared to those with 20+ teeth, tooth loss was associated with a gradual increase in mortality, with an adjusted HR of 1.14 (95% CI, 1.06 to 1.23) for those with 10-19 teeth, 1.23 (95% CI, 1.15 to 1.31) for those with 1-9 teeth, and 1.35 (95% CI, 1.26 to 1.44) for those without natural teeth. Denture use was associated with lower risk of mortality (adjusted HR 0.81; 95% CI, 0.77 to 0.84). Subgroup analyses indicated that the benefit of denture use was greater in men than in women (P = 0.02) and tended to decrease with age (P < 0.001). The effects of denture use did not differ among various degrees of tooth loss (P = 0.17). CONCLUSIONS: Tooth loss was associated with an increased risk of mortality in older adults. Denture use provided a protective effect against death for all degrees of tooth loss however, this effect appeared to be modified by sex and age. SN - 1472-6831 UR - https://www.unboundmedicine.com/medline/citation/32276615/Number_of_natural_teeth,_denture_use_and_mortality_in_Chinese_elderly:_a_population-based_prospective_cohort_study L2 - https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-020-01084-9 DB - PRIME DP - Unbound Medicine ER -
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