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Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019.
J Microbiol Immunol Infect. 2020 Jun; 53(3):473-480.JM

Abstract

OBJECTIVE

To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19).

METHODS

From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. Patients were followed up to March 10, 2020, and dynamic profiles of nucleic acid testing results in throat swabs and fecal specimens were closely monitored.

RESULTS

Clearance of SARS-CoV-2 in respiratory tract occurred within two weeks after abatement of fever, whereas viral RNA remained detectable in stools of pediatric patients for longer than 4 weeks. Two children had fecal SARS-CoV-2 undetectable 20 days after throat swabs showing negative, while that of another child lagged behind for 8 days.

CONCLUSIONS

SARS-CoV-2 may exist in children's gastrointestinal tract for a longer time than respiratory system. Persistent shedding of SARS-CoV-2 in stools of infected children raises the possibility that the virus might be transmitted through contaminated fomites. Massive efforts should be made at all levels to prevent spreading of the infection among children after reopening of kindergartens and schools.

Links

Publisher Full Text
ncbi.nlm.nih.gov
linkinghub.elsevier.com
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Authors+Show Affiliations

Xing YH
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Ni W
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Wu Q
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Li WJ
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Li GJ
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Wang WD
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Tong JN
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Song XF
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China.
Wing-Kin Wong G
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: wingkinwong@cuhk.edu.hk.
Xing QS
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province, China. Electronic address: xingqs0532@163.com.

MeSH

BetacoronavirusCOVID-19ChildChild, PreschoolChinaCoronavirus InfectionsFecesFemaleGastrointestinal TractHumansInfantMalePandemicsPneumonia, ViralRNA, ViralRespiratory SystemSARS-CoV-2Virus Shedding

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32276848

Citation

Xing, Yu-Han, et al. "Prolonged Viral Shedding in Feces of Pediatric Patients With Coronavirus Disease 2019." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 53, no. 3, 2020, pp. 473-480.
Xing YH, Ni W, Wu Q, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. J Microbiol Immunol Infect. 2020;53(3):473-480.
Xing, Y. H., Ni, W., Wu, Q., Li, W. J., Li, G. J., Wang, W. D., Tong, J. N., Song, X. F., Wing-Kin Wong, G., & Xing, Q. S. (2020). Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 53(3), 473-480. https://doi.org/10.1016/j.jmii.2020.03.021
Xing YH, et al. Prolonged Viral Shedding in Feces of Pediatric Patients With Coronavirus Disease 2019. J Microbiol Immunol Infect. 2020;53(3):473-480. PubMed PMID: 32276848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. AU - Xing,Yu-Han, AU - Ni,Wei, AU - Wu,Qin, AU - Li,Wen-Jie, AU - Li,Guo-Ju, AU - Wang,Wen-Di, AU - Tong,Jian-Ning, AU - Song,Xiu-Feng, AU - Wing-Kin Wong,Gary, AU - Xing,Quan-Sheng, Y1 - 2020/03/28/ PY - 2020/03/20/received PY - 2020/03/24/revised PY - 2020/03/25/accepted PY - 2020/4/12/pubmed PY - 2020/6/17/medline PY - 2020/4/12/entrez KW - COVID-19 KW - Fecal shedding KW - Pediatric patient KW - SARS-CoV-2 SP - 473 EP - 480 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 53 IS - 3 N2 - OBJECTIVE: To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19). METHODS: From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. Patients were followed up to March 10, 2020, and dynamic profiles of nucleic acid testing results in throat swabs and fecal specimens were closely monitored. RESULTS: Clearance of SARS-CoV-2 in respiratory tract occurred within two weeks after abatement of fever, whereas viral RNA remained detectable in stools of pediatric patients for longer than 4 weeks. Two children had fecal SARS-CoV-2 undetectable 20 days after throat swabs showing negative, while that of another child lagged behind for 8 days. CONCLUSIONS: SARS-CoV-2 may exist in children's gastrointestinal tract for a longer time than respiratory system. Persistent shedding of SARS-CoV-2 in stools of infected children raises the possibility that the virus might be transmitted through contaminated fomites. Massive efforts should be made at all levels to prevent spreading of the infection among children after reopening of kindergartens and schools. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/32276848/Prolonged_viral_shedding_in_feces_of_pediatric_patients_with_coronavirus_disease_2019_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1684-1182(20)30081-5 DB - PRIME DP - Unbound Medicine ER -