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Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography.
Int J Cardiovasc Imaging. 2020 Jul; 36(7):1311-1319.IJ

Abstract

Left ventricular (LV) function undergoes subtle changes (subclinical left ventricular dysfunction) in a large proportion of patients with type 2 diabetes (T2DM) who develop diabetic cardiomyopathy. This study aimed to quantify LV myocardial strain and synchrony in T2DM by real-time three-dimensional echocardiography (RT-3DE), and to evaluate subclinical LV dysfunction in T2DM at different glycemic control levels. Seventy-two patients with T2DM with an LV ejection fraction (LVEF) ≥ 55% and 45 healthy individuals as controls who underwent RT-3DE were studied. Patients were also subdivided into the DMa group (glycosylated hemoglobin < 7%, n = 38) and the DMb group (glycosylated hemoglobin ≥ 7%, n = 34). Three-dimensional strain and synchronization parameters of the left ventricle were measured by RT-3DE and compared among the three groups. Despite a similar LVEF, global longitudinal strain (GLS), global circumferential strain (GCS), and global area strain (GAS) in the DMb group were lower, and the standard deviation of peak time (Tm-SD) and the maximum difference in peak time (Tm-Dif) in the DMb group higher, than those in the control and DMa groups (all p < 0.05). Multivariable linear regression analysis showed that the duration of diabetes was independently associated with GCS (β = - 0.516, p < 0.001) and GAS (β = - 0.391, p = 0.005). HbA1c levels were independently associated with GLS (β = - 0.675, p < 0.001), Tm-SD (β = 3.363, p < 0.001), and Tm-Dif (β = 3.895, p < 0.001). RT-3DE can detect subclinical myocardial dysfunction in poor glycemic control of T2DM, and myocardial dysfunction is associated with the duration of diabetes and HbA1c.

Authors+Show Affiliations

Department of Ultrasound, Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan, Shanxi Province, People's Republic of China. xiaoguoguo119@163.com.Department of Medical Imaging, Shanxi Armed Police Force Hospital, Taiyuan, Shanxi Province, People's Republic of China.Department of Ultrasound, Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan, Shanxi Province, People's Republic of China.Department of Ultrasound, Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan, Shanxi Province, People's Republic of China.Department of Ultrasound, Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan, Shanxi Province, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32277320

Citation

Chen, Xiaoyan, et al. "Quantitative Evaluation of Subclinical Left Ventricular Dysfunction in Patients With Type 2 Diabetes Mellitus By Three-dimensional Echocardiography." The International Journal of Cardiovascular Imaging, vol. 36, no. 7, 2020, pp. 1311-1319.
Chen X, Guo H, Yang Q, et al. Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography. Int J Cardiovasc Imaging. 2020;36(7):1311-1319.
Chen, X., Guo, H., Yang, Q., Fang, J., & Kang, X. (2020). Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography. The International Journal of Cardiovascular Imaging, 36(7), 1311-1319. https://doi.org/10.1007/s10554-020-01833-5
Chen X, et al. Quantitative Evaluation of Subclinical Left Ventricular Dysfunction in Patients With Type 2 Diabetes Mellitus By Three-dimensional Echocardiography. Int J Cardiovasc Imaging. 2020;36(7):1311-1319. PubMed PMID: 32277320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography. AU - Chen,Xiaoyan, AU - Guo,Haifeng, AU - Yang,Qingmei, AU - Fang,Jianxiu, AU - Kang,Xiaoyan, Y1 - 2020/04/10/ PY - 2019/12/17/received PY - 2020/03/30/accepted PY - 2020/4/12/pubmed PY - 2020/9/29/medline PY - 2020/4/12/entrez KW - Echocardiography KW - Left ventricular dysfunction KW - Real-time three-dimensional speckle-tracking imaging KW - Subclinical myocardial dysfunction KW - Type 2 diabetes mellitus SP - 1311 EP - 1319 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 36 IS - 7 N2 - Left ventricular (LV) function undergoes subtle changes (subclinical left ventricular dysfunction) in a large proportion of patients with type 2 diabetes (T2DM) who develop diabetic cardiomyopathy. This study aimed to quantify LV myocardial strain and synchrony in T2DM by real-time three-dimensional echocardiography (RT-3DE), and to evaluate subclinical LV dysfunction in T2DM at different glycemic control levels. Seventy-two patients with T2DM with an LV ejection fraction (LVEF) ≥ 55% and 45 healthy individuals as controls who underwent RT-3DE were studied. Patients were also subdivided into the DMa group (glycosylated hemoglobin < 7%, n = 38) and the DMb group (glycosylated hemoglobin ≥ 7%, n = 34). Three-dimensional strain and synchronization parameters of the left ventricle were measured by RT-3DE and compared among the three groups. Despite a similar LVEF, global longitudinal strain (GLS), global circumferential strain (GCS), and global area strain (GAS) in the DMb group were lower, and the standard deviation of peak time (Tm-SD) and the maximum difference in peak time (Tm-Dif) in the DMb group higher, than those in the control and DMa groups (all p < 0.05). Multivariable linear regression analysis showed that the duration of diabetes was independently associated with GCS (β = - 0.516, p < 0.001) and GAS (β = - 0.391, p = 0.005). HbA1c levels were independently associated with GLS (β = - 0.675, p < 0.001), Tm-SD (β = 3.363, p < 0.001), and Tm-Dif (β = 3.895, p < 0.001). RT-3DE can detect subclinical myocardial dysfunction in poor glycemic control of T2DM, and myocardial dysfunction is associated with the duration of diabetes and HbA1c. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/32277320/Quantitative_evaluation_of_subclinical_left_ventricular_dysfunction_in_patients_with_type_2_diabetes_mellitus_by_three_dimensional_echocardiography_ L2 - https://doi.org/10.1007/s10554-020-01833-5 DB - PRIME DP - Unbound Medicine ER -