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Effects of vanadate on EP and its distribution in guinea pig cochlea.
Acta Otolaryngol Suppl. 1988; 456:117-23.AO

Abstract

Effects of sigma-sodium vanadate on endocochlear d.c. potential (EP) and cochlear microphonic potential (CM) were examined and its distribution was observed by an X-ray microanalyzer in the guinea pig cochlea. The perilymphatic space was perfused with 1, 5, and 10 mM solutions of sodium vanadate, using a Harvard Microperfusion pump. By perfusing the scala vestibuli, EP and CM showed a rapid decrease. On the other hand, by perfusing the scala tympani, EP showed an overshoot at first, then a gradual decrease, while CM showed only a gradual decrease. The rates of decrease of EP and CM were dependent upon perfusion time and vanadate concentration. After the electrophysiological examinations, the specimen of the cochlea was observed by X-ray microanalyzer. An accumulation of vanadium was confirmed, especially in the stria vascularis and the hair cells. From the results obtained, the possibility of the responsibility of vanadate for a hypothetical sudden deafness originating in the stria vascularis was discussed.

Authors+Show Affiliations

Kagoshima Immaculate Heart College, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3227821

Citation

Nakano, T, and T Morimitsu. "Effects of Vanadate On EP and Its Distribution in Guinea Pig Cochlea." Acta Oto-laryngologica. Supplementum, vol. 456, 1988, pp. 117-23.
Nakano T, Morimitsu T. Effects of vanadate on EP and its distribution in guinea pig cochlea. Acta Otolaryngol Suppl. 1988;456:117-23.
Nakano, T., & Morimitsu, T. (1988). Effects of vanadate on EP and its distribution in guinea pig cochlea. Acta Oto-laryngologica. Supplementum, 456, 117-23.
Nakano T, Morimitsu T. Effects of Vanadate On EP and Its Distribution in Guinea Pig Cochlea. Acta Otolaryngol Suppl. 1988;456:117-23. PubMed PMID: 3227821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vanadate on EP and its distribution in guinea pig cochlea. AU - Nakano,T, AU - Morimitsu,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 117 EP - 23 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 456 N2 - Effects of sigma-sodium vanadate on endocochlear d.c. potential (EP) and cochlear microphonic potential (CM) were examined and its distribution was observed by an X-ray microanalyzer in the guinea pig cochlea. The perilymphatic space was perfused with 1, 5, and 10 mM solutions of sodium vanadate, using a Harvard Microperfusion pump. By perfusing the scala vestibuli, EP and CM showed a rapid decrease. On the other hand, by perfusing the scala tympani, EP showed an overshoot at first, then a gradual decrease, while CM showed only a gradual decrease. The rates of decrease of EP and CM were dependent upon perfusion time and vanadate concentration. After the electrophysiological examinations, the specimen of the cochlea was observed by X-ray microanalyzer. An accumulation of vanadium was confirmed, especially in the stria vascularis and the hair cells. From the results obtained, the possibility of the responsibility of vanadate for a hypothetical sudden deafness originating in the stria vascularis was discussed. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/3227821/Effects_of_vanadate_on_EP_and_its_distribution_in_guinea_pig_cochlea_ DB - PRIME DP - Unbound Medicine ER -