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Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms.
Int Forum Allergy Rhinol. 2020 07; 10(7):806-813.IF

Abstract

BACKGROUND

Rapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID-19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID-19 may help facilitate screening and early isolation of cases.

METHODS

A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for COVID-19. Logistic regression was employed to identify symptoms associated with COVID-19 positivity.

RESULTS

A total of 1480 patients with influenza-like symptoms underwent COVID-19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID-19-positive patients and 203 of 1378 (15%) COVID-19-negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID-19-positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID-19-negative patients (p < 0.001). Smell and taste impairment were independently and strongly associated with COVID-19 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08-23.5; ageusia: aOR 10.2; 95% CI, 4.74-22.1), whereas sore throat was associated with COVID-19 negativity (aOR 0.23; 95% CI, 0.11-0.50). Of patients who reported COVID-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness.

CONCLUSION

In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with COVID-19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease-related symptoms.

Authors+Show Affiliations

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA. University of California San Diego School of Medicine, La Jolla, CA.Department of Radiology, University of California San Diego Health, La Jolla, CA.Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32279441

Citation

Yan, Carol H., et al. "Association of Chemosensory Dysfunction and COVID-19 in Patients Presenting With Influenza-like Symptoms." International Forum of Allergy & Rhinology, vol. 10, no. 7, 2020, pp. 806-813.
Yan CH, Faraji F, Prajapati DP, et al. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020;10(7):806-813.
Yan, C. H., Faraji, F., Prajapati, D. P., Boone, C. E., & DeConde, A. S. (2020). Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. International Forum of Allergy & Rhinology, 10(7), 806-813. https://doi.org/10.1002/alr.22579
Yan CH, et al. Association of Chemosensory Dysfunction and COVID-19 in Patients Presenting With Influenza-like Symptoms. Int Forum Allergy Rhinol. 2020;10(7):806-813. PubMed PMID: 32279441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. AU - Yan,Carol H, AU - Faraji,Farhoud, AU - Prajapati,Divya P, AU - Boone,Christine E, AU - DeConde,Adam S, Y1 - 2020/06/01/ PY - 2020/04/05/received PY - 2020/04/06/revised PY - 2020/04/06/accepted PY - 2020/4/13/pubmed PY - 2020/7/22/medline PY - 2020/4/13/entrez KW - COVID-19 KW - patient outcomes KW - smell loss KW - taste loss SP - 806 EP - 813 JF - International forum of allergy & rhinology JO - Int Forum Allergy Rhinol VL - 10 IS - 7 N2 - BACKGROUND: Rapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID-19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID-19 may help facilitate screening and early isolation of cases. METHODS: A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for COVID-19. Logistic regression was employed to identify symptoms associated with COVID-19 positivity. RESULTS: A total of 1480 patients with influenza-like symptoms underwent COVID-19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID-19-positive patients and 203 of 1378 (15%) COVID-19-negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID-19-positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID-19-negative patients (p < 0.001). Smell and taste impairment were independently and strongly associated with COVID-19 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08-23.5; ageusia: aOR 10.2; 95% CI, 4.74-22.1), whereas sore throat was associated with COVID-19 negativity (aOR 0.23; 95% CI, 0.11-0.50). Of patients who reported COVID-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness. CONCLUSION: In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with COVID-19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease-related symptoms. SN - 2042-6984 UR - https://www.unboundmedicine.com/medline/citation/32279441/Association_of_chemosensory_dysfunction_and_COVID_19_in_patients_presenting_with_influenza_like_symptoms_ L2 - https://doi.org/10.1002/alr.22579 DB - PRIME DP - Unbound Medicine ER -