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Mesenchymal Stem Cell Therapy for COVID-19: Present or Future.
Stem Cell Rev Rep. 2020 06; 16(3):427-433.SC

Abstract

"COVID-19" is the word that certainly isn't forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, no standard treatment for this disease has been discovered to date. Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. After the intravenous transplantation of MSCs, a significant population of cells accumulates in the lung, which they alongside immunomodulatory effect could protect alveolar epithelial cells, reclaim the pulmonary microenvironment, prevent pulmonary fibrosis, and cure lung dysfunction. Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. In this study, we considered this new approach to improve patient's immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing.

Authors+Show Affiliations

Department of Clinical Biochemistry and Applied Cell Science, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. agolchin.vet10@yahoo.com.Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran.Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. r.ardeshiry.62@gmail.com. SinaCell Research and Product Center, Tehran, Iran. r.ardeshiry.62@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32281052

Citation

Golchin, Ali, et al. "Mesenchymal Stem Cell Therapy for COVID-19: Present or Future." Stem Cell Reviews and Reports, vol. 16, no. 3, 2020, pp. 427-433.
Golchin A, Seyedjafari E, Ardeshirylajimi A. Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Rev Rep. 2020;16(3):427-433.
Golchin, A., Seyedjafari, E., & Ardeshirylajimi, A. (2020). Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Reviews and Reports, 16(3), 427-433. https://doi.org/10.1007/s12015-020-09973-w
Golchin A, Seyedjafari E, Ardeshirylajimi A. Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Rev Rep. 2020;16(3):427-433. PubMed PMID: 32281052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. AU - Golchin,Ali, AU - Seyedjafari,Ehsan, AU - Ardeshirylajimi,Abdolreza, PY - 2020/4/14/pubmed PY - 2020/6/3/medline PY - 2020/4/14/entrez KW - COVID-19 KW - Clinical trials KW - Coronavirus KW - Immunomodulatory KW - Mesenchymal stem cell KW - Stem cell therapy SP - 427 EP - 433 JF - Stem cell reviews and reports JO - Stem Cell Rev Rep VL - 16 IS - 3 N2 - "COVID-19" is the word that certainly isn't forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, no standard treatment for this disease has been discovered to date. Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. After the intravenous transplantation of MSCs, a significant population of cells accumulates in the lung, which they alongside immunomodulatory effect could protect alveolar epithelial cells, reclaim the pulmonary microenvironment, prevent pulmonary fibrosis, and cure lung dysfunction. Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. In this study, we considered this new approach to improve patient's immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. SN - 2629-3277 UR - https://www.unboundmedicine.com/medline/citation/32281052/Mesenchymal_Stem_Cell_Therapy_for_COVID_19:_Present_or_Future_ DB - PRIME DP - Unbound Medicine ER -