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A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease-19 (COVID-19).
Int J Rheum Dis. 2020 May; 23(5):613-619.IJ

Abstract

OBJECTIVE

The pandemic coronavirus disease-19 (COVID-19) has pushed the global healthcare system to a crisis and amounted to a huge economic burden. Different drugs for prophylaxis against COVID-19 including chloroquine (CQ) or hydroxychloroquine (HCQ) have been tried. This study was performed to systematically review the role of CQ and HCQ in preventing the spread of COVID-19.

METHODS

PubMed, EMBASE, ClinicalTrials.gov, International Clinical Trials Registry Platform and Cochrane Library databases were searched for studies that evaluated the prophylactic role of CQ or HCQ on SARS-CoV-2 (pre-clinical studies) or COVID-19 (clinical studies) until 30 March 2020. The available literature was critically appraised.

RESULTS

A total of 45 articles were screened and 5 (3 in vitro pre-clinical studies and 2 clinical opinions) were included. The pre-clinical studies showed the prophylactic effects of CQ and HCQ against SARS-CoV-2. On the other hand, the clinical opinions advocated the prophylactic use of CQ and HCQ against COVID-19. However, no original clinical studies on the prophylactic role of CQ or HCQ on COVID-19 were available.

CONCLUSION

Although pre-clinical results are promising, to date there is a dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19. Considering potential safety issues and the likelihood of imparting a false sense of security, prophylaxis with CQ or HCQ against COVID-19 needs to be thoroughly evaluated in observational studies or high-quality randomized controlled studies.

Authors+Show Affiliations

Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Department of Clinical Immunology and Rheumatology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32281213

Citation

Shah, Sanket, et al. "A Systematic Review of the Prophylactic Role of Chloroquine and Hydroxychloroquine in Coronavirus Disease-19 (COVID-19)." International Journal of Rheumatic Diseases, vol. 23, no. 5, 2020, pp. 613-619.
Shah S, Das S, Jain A, et al. A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease-19 (COVID-19). Int J Rheum Dis. 2020;23(5):613-619.
Shah, S., Das, S., Jain, A., Misra, D. P., & Negi, V. S. (2020). A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease-19 (COVID-19). International Journal of Rheumatic Diseases, 23(5), 613-619. https://doi.org/10.1111/1756-185X.13842
Shah S, et al. A Systematic Review of the Prophylactic Role of Chloroquine and Hydroxychloroquine in Coronavirus Disease-19 (COVID-19). Int J Rheum Dis. 2020;23(5):613-619. PubMed PMID: 32281213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease-19 (COVID-19). AU - Shah,Sanket, AU - Das,Saibal, AU - Jain,Avinash, AU - Misra,Durga Prasanna, AU - Negi,Vir Singh, Y1 - 2020/04/27/ PY - 2020/3/26/received PY - 2020/3/30/revised PY - 2020/3/30/accepted PY - 2020/4/14/pubmed PY - 2020/6/4/medline PY - 2020/4/14/entrez KW - COVID-19 KW - SARS-CoV-2 KW - chloroquine KW - high-risk KW - hydroxychloroquine KW - prevention SP - 613 EP - 619 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 23 IS - 5 N2 - OBJECTIVE: The pandemic coronavirus disease-19 (COVID-19) has pushed the global healthcare system to a crisis and amounted to a huge economic burden. Different drugs for prophylaxis against COVID-19 including chloroquine (CQ) or hydroxychloroquine (HCQ) have been tried. This study was performed to systematically review the role of CQ and HCQ in preventing the spread of COVID-19. METHODS: PubMed, EMBASE, ClinicalTrials.gov, International Clinical Trials Registry Platform and Cochrane Library databases were searched for studies that evaluated the prophylactic role of CQ or HCQ on SARS-CoV-2 (pre-clinical studies) or COVID-19 (clinical studies) until 30 March 2020. The available literature was critically appraised. RESULTS: A total of 45 articles were screened and 5 (3 in vitro pre-clinical studies and 2 clinical opinions) were included. The pre-clinical studies showed the prophylactic effects of CQ and HCQ against SARS-CoV-2. On the other hand, the clinical opinions advocated the prophylactic use of CQ and HCQ against COVID-19. However, no original clinical studies on the prophylactic role of CQ or HCQ on COVID-19 were available. CONCLUSION: Although pre-clinical results are promising, to date there is a dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19. Considering potential safety issues and the likelihood of imparting a false sense of security, prophylaxis with CQ or HCQ against COVID-19 needs to be thoroughly evaluated in observational studies or high-quality randomized controlled studies. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/32281213/A_systematic_review_of_the_prophylactic_role_of_chloroquine_and_hydroxychloroquine_in_coronavirus_disease_19__COVID_19__ DB - PRIME DP - Unbound Medicine ER -