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Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors.
J Cosmet Dermatol. 2020 Apr 12 [Online ahead of print]JC

Abstract

BACKGROUND

Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. It is usually reported to be clinically and histologically similar to alopecia areata.

AIMS

We report a case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, its management and some pathogenetic hypotheses.

PATIENT

Herein, we report the first case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, firstly appeared as a lichen planopilaris. Topical steroids and fusidic acid cream were applied with partial benefit and a scaring outcome. No discontinuation of nivolumab was required.

CONCLUSION

Immune checkpoint inhibitors induced inflammatory response leads to the exposure of hair follicle antigens and a consequent loss of Immuno Privilege. We hypothesize a role of steroids in deviating a primarily lichenoid reaction toward a folliculitis.

Authors+Show Affiliations

Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32281235

Citation

Rossi, Alfredo, et al. "Eosinophilic Folliculitis of the Scalp Associated With PD-1/PDL1 Inhibitors." Journal of Cosmetic Dermatology, 2020.
Rossi A, Magri F, Caro G, et al. Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors. J Cosmet Dermatol. 2020.
Rossi, A., Magri, F., Caro, G., Federico, A., Fortuna, M. C., Soda, G., De Vincentiis, L., & Carlesimo, M. (2020). Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.13388
Rossi A, et al. Eosinophilic Folliculitis of the Scalp Associated With PD-1/PDL1 Inhibitors. J Cosmet Dermatol. 2020 Apr 12; PubMed PMID: 32281235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors. AU - Rossi,Alfredo, AU - Magri,Francesca, AU - Caro,Gemma, AU - Federico,Alessandro, AU - Fortuna,Maria Caterina, AU - Soda,Giuseppe, AU - De Vincentiis,Ludovica, AU - Carlesimo,Marta, Y1 - 2020/04/12/ PY - 2020/02/15/received PY - 2020/03/02/revised PY - 2020/03/09/accepted PY - 2020/4/14/entrez KW - folliculitis KW - hair KW - immune checkpoint KW - nivolumab KW - scaring alopecia JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol N2 - BACKGROUND: Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. It is usually reported to be clinically and histologically similar to alopecia areata. AIMS: We report a case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, its management and some pathogenetic hypotheses. PATIENT: Herein, we report the first case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, firstly appeared as a lichen planopilaris. Topical steroids and fusidic acid cream were applied with partial benefit and a scaring outcome. No discontinuation of nivolumab was required. CONCLUSION: Immune checkpoint inhibitors induced inflammatory response leads to the exposure of hair follicle antigens and a consequent loss of Immuno Privilege. We hypothesize a role of steroids in deviating a primarily lichenoid reaction toward a folliculitis. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/32281235/Eosinophilic_folliculitis_of_the_scalp_associated_with_PD-1/PDL1_inhibitors L2 - https://doi.org/10.1111/jocd.13388 DB - PRIME DP - Unbound Medicine ER -
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