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Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review.
J Toxicol Environ Health B Crit Rev. 2020 05 18; 23(4):177-181.JT

Abstract

As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested in vivo and in vitro for the ability to inhibit the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, even though investigators noted the therapeutic potential of these drugs, it is important to consider the toxicological risks and necessary care for rational use of CQ and HCQ. This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests.

Authors+Show Affiliations

Institute of Geography, Department of Environmental Health, Federal University of Uberlândia, Santa Mônica Campus, Uberlândia, Brazil. Institute of Biotechnology, Department of Genetics and Biochemistry, Federal University of Uberlândia, Umuarama Campus, Uberlândia, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32281481

Citation

Pereira, Boscolli Barbosa. "Challenges and Cares to Promote Rational Use of Chloroquine and Hydroxychloroquine in the Management of Coronavirus Disease 2019 (COVID-19) Pandemic: a Timely Review." Journal of Toxicology and Environmental Health. Part B, Critical Reviews, vol. 23, no. 4, 2020, pp. 177-181.
Pereira BB. Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review. J Toxicol Environ Health B Crit Rev. 2020;23(4):177-181.
Pereira, B. B. (2020). Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review. Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 23(4), 177-181. https://doi.org/10.1080/10937404.2020.1752340
Pereira BB. Challenges and Cares to Promote Rational Use of Chloroquine and Hydroxychloroquine in the Management of Coronavirus Disease 2019 (COVID-19) Pandemic: a Timely Review. J Toxicol Environ Health B Crit Rev. 2020 05 18;23(4):177-181. PubMed PMID: 32281481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review. A1 - Pereira,Boscolli Barbosa, Y1 - 2020/04/12/ PY - 2020/4/14/pubmed PY - 2020/5/7/medline PY - 2020/4/14/entrez KW - Toxicology KW - health care KW - public health KW - retinopathy KW - screening SP - 177 EP - 181 JF - Journal of toxicology and environmental health. Part B, Critical reviews JO - J Toxicol Environ Health B Crit Rev VL - 23 IS - 4 N2 - As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested in vivo and in vitro for the ability to inhibit the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, even though investigators noted the therapeutic potential of these drugs, it is important to consider the toxicological risks and necessary care for rational use of CQ and HCQ. This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests. SN - 1521-6950 UR - https://www.unboundmedicine.com/medline/citation/32281481/Challenges_and_cares_to_promote_rational_use_of_chloroquine_and_hydroxychloroquine_in_the_management_of_coronavirus_disease_2019__COVID_19__pandemic:_a_timely_review_ L2 - https://www.tandfonline.com/doi/full/10.1080/10937404.2020.1752340 DB - PRIME DP - Unbound Medicine ER -