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Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide.
J Med Food. 2020 Jun; 23(6):584-592.JM

Abstract

Studies have confirmed that Angelica sinensis, which is a famous medicinal food in China, can effectively alleviate the symptoms of ulcerative colitis (UC) in rats. However, as the major water-soluble ingredient, the specific effects of A. sinensis polysaccharide (ASP) on UC and potential mechanisms were uncertain. In this study, we aimed to elucidate the protective effects of ASP on dextran sulfate sodium (DSS)-induced UC and to further explore the mechanisms. ASP could significantly ameliorate the symptoms of weight loss, disease activity index score, and colon shortening caused by DSS. ASP treatment also significantly suppressed the myeloperoxidase activity in colon tissues. Furthermore, after ASP administration, the expression of the proinflammatory cytokines (interleukin [IL]-6, IL-1β, and tumor necrosis factor alpha) induced by DSS was remarkably suppressed, and there was a definite improvement in the expressions of tight junction proteins, such as zona occludens 1, occludin, and claudin-1. In addition, the results of apoptosis experiments showed that the apoptotic events were noticeably reduced after ASP treatment. Taken together, these results suggested that ASP may be a potential natural agent against UC.

Authors+Show Affiliations

Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32282259

Citation

Cheng, Fang, et al. "Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice By Angelica Sinensis Polysaccharide." Journal of Medicinal Food, vol. 23, no. 6, 2020, pp. 584-592.
Cheng F, Zhang Y, Li Q, et al. Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide. J Med Food. 2020;23(6):584-592.
Cheng, F., Zhang, Y., Li, Q., Zeng, F., & Wang, K. (2020). Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide. Journal of Medicinal Food, 23(6), 584-592. https://doi.org/10.1089/jmf.2019.4607
Cheng F, et al. Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice By Angelica Sinensis Polysaccharide. J Med Food. 2020;23(6):584-592. PubMed PMID: 32282259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide. AU - Cheng,Fang, AU - Zhang,Yu, AU - Li,Qiang, AU - Zeng,Fang, AU - Wang,Kaiping, Y1 - 2020/04/13/ PY - 2020/4/14/pubmed PY - 2021/3/5/medline PY - 2020/4/14/entrez KW - Angelica sinensis polysaccharide KW - apoptosis KW - proinflammatory KW - tight junction proteins KW - ulcerative colitis SP - 584 EP - 592 JF - Journal of medicinal food JO - J Med Food VL - 23 IS - 6 N2 - Studies have confirmed that Angelica sinensis, which is a famous medicinal food in China, can effectively alleviate the symptoms of ulcerative colitis (UC) in rats. However, as the major water-soluble ingredient, the specific effects of A. sinensis polysaccharide (ASP) on UC and potential mechanisms were uncertain. In this study, we aimed to elucidate the protective effects of ASP on dextran sulfate sodium (DSS)-induced UC and to further explore the mechanisms. ASP could significantly ameliorate the symptoms of weight loss, disease activity index score, and colon shortening caused by DSS. ASP treatment also significantly suppressed the myeloperoxidase activity in colon tissues. Furthermore, after ASP administration, the expression of the proinflammatory cytokines (interleukin [IL]-6, IL-1β, and tumor necrosis factor alpha) induced by DSS was remarkably suppressed, and there was a definite improvement in the expressions of tight junction proteins, such as zona occludens 1, occludin, and claudin-1. In addition, the results of apoptosis experiments showed that the apoptotic events were noticeably reduced after ASP treatment. Taken together, these results suggested that ASP may be a potential natural agent against UC. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/32282259/Inhibition_of_Dextran_Sodium_Sulfate-Induced_Experimental_Colitis_in_Mice_by_Angelica_Sinensis_Polysaccharide. L2 - https://www.liebertpub.com/doi/10.1089/jmf.2019.4607?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -