TY - JOUR T1 - Pepsin and acid secretions during and after gastric operations in patients with duodenal ulcer. AU - Nagamachi,Y, AU - Skoryna,S C, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 239-41,243 JF - Canadian journal of surgery. Journal canadien de chirurgie JO - Can J Surg VL - 20 IS - 3 N2 - Measurement of gastric pepsin and acid secretion was performed before, during and after selective vagotomy with antrectomy (SVA) and Billroth I gastrectomy (B-I) in 20 patients with a duodenal ulcer. Preoperative pepsin concentration increased during operation and decreased gradually 72 hours after SVA and 1 to 3 months after B-I. Although the pepsin concentration decreased substantially, it was never less than 70% of the preoperative level in both groups. Acid concentration decreased immediately after vagotomy in the SVA group and decreased gradually after 72 hours in the B-I group. Although there was a notable increase in the pH in both groups after operation, a pH of 5 was never reached. Decrease in gastric secretory volume (about 50%) was approximately equal in both groups. It appears that any increase in acid secretion occurring after vagotomy or gastrectomy may be sufficient to activate high-and low-pH-acting pepsins. Extravagal and extraantral stimulation of gastric pepsin secretion after operation should be considered an important etiologic factor in the pathogenesis of recurrent ulcer. SN - 0008-428X UR - https://www.unboundmedicine.com/medline/citation/322831/Pepsin_and_acid_secretions_during_and_after_gastric_operations_in_patients_with_duodenal_ulcer_ L2 - https://www.canjsurg.ca/lookup/pmidlookup?view=long&pmid=322831 DB - PRIME DP - Unbound Medicine ER -