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Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms.
Ear Nose Throat J. 2020 Nov; 99(9):569-576.EN

Abstract

AIM

Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases.

METHODS

We searched PubMed and Web of Science electronic databases.

RESULTS

We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. Pooled data revealed that pharyngodynia was present in 12.4% of patients, nasal congestion in 3.7%, and rhinorrhea was rare. No reports on COVID-19 and olfactory/gustative disorders matched inclusion criteria but preliminary evidences suggested they could be present. Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). Frequent comorbidities were hypertension (17.4%), diabetes (3.8%), and coronary heart disease (3.8%); 83% of patients had alterations on chest computed tomography that were bilateral in 89.5% of cases. Ground-glass opacity was the most common finding (50%). Lymphopenia (77.2%) and leucopenia (30.1%) were common. Critical cases with complications were 9%, intensive care unit admission was required in 7.3%, invasive ventilation in 3.4%, and mortality was 2.4%.

CONCLUSION

Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. Clinical presentation together with radiological and laboratory findings could help to identify suspected cases.

Authors+Show Affiliations

Department of Neurosciences, 60242University of Padova, Audiology Unit at Treviso Hospital, Treviso, Italy.Department of Neurosciences, 60242University of Padova, Audiology Unit at Treviso Hospital, Treviso, Italy.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32283980

Citation

Lovato, Andrea, and Cosimo de Filippis. "Clinical Presentation of COVID-19: a Systematic Review Focusing On Upper Airway Symptoms." Ear, Nose, & Throat Journal, vol. 99, no. 9, 2020, pp. 569-576.
Lovato A, de Filippis C. Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear Nose Throat J. 2020;99(9):569-576.
Lovato, A., & de Filippis, C. (2020). Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear, Nose, & Throat Journal, 99(9), 569-576. https://doi.org/10.1177/0145561320920762
Lovato A, de Filippis C. Clinical Presentation of COVID-19: a Systematic Review Focusing On Upper Airway Symptoms. Ear Nose Throat J. 2020;99(9):569-576. PubMed PMID: 32283980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. AU - Lovato,Andrea, AU - de Filippis,Cosimo, Y1 - 2020/04/13/ PY - 2020/4/15/pubmed PY - 2020/10/24/medline PY - 2020/4/15/entrez KW - COVID-19 KW - SARS-CoV-2 KW - nasal congestion KW - pharyngodynia KW - smell KW - taste SP - 569 EP - 576 JF - Ear, nose, & throat journal JO - Ear Nose Throat J VL - 99 IS - 9 N2 - AIM: Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. METHODS: We searched PubMed and Web of Science electronic databases. RESULTS: We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. Pooled data revealed that pharyngodynia was present in 12.4% of patients, nasal congestion in 3.7%, and rhinorrhea was rare. No reports on COVID-19 and olfactory/gustative disorders matched inclusion criteria but preliminary evidences suggested they could be present. Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). Frequent comorbidities were hypertension (17.4%), diabetes (3.8%), and coronary heart disease (3.8%); 83% of patients had alterations on chest computed tomography that were bilateral in 89.5% of cases. Ground-glass opacity was the most common finding (50%). Lymphopenia (77.2%) and leucopenia (30.1%) were common. Critical cases with complications were 9%, intensive care unit admission was required in 7.3%, invasive ventilation in 3.4%, and mortality was 2.4%. CONCLUSION: Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. Clinical presentation together with radiological and laboratory findings could help to identify suspected cases. SN - 1942-7522 UR - https://www.unboundmedicine.com/medline/citation/32283980/Clinical_Presentation_of_COVID_19:_A_Systematic_Review_Focusing_on_Upper_Airway_Symptoms_ L2 - https://journals.sagepub.com/doi/10.1177/0145561320920762?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -