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A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin.
Antimicrob Agents Chemother. 2020 05 21; 64(6)AA

Abstract

We report the first clinical Escherichia coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, Δ6-11 (RPISLR), in pmrB that contributes to colistin resistance was verified using recombinant DNA techniques. Although being less fit than the wild-type (WT) strain or EC3000 revertant (chromosomal replacement of WT pmrB in EC3000), a portion of serially passaged EC3000 strains preserving colistin resistance without selective pressure raises the concern for further spread.

Authors+Show Affiliations

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.Division of Infectious Diseases, Department of Medicine, Veterans General Hospital, Taipei, Taiwan.Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan linjungchung1@yahoo.com.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32284375

Citation

Wang, Ching-Hsun, et al. "A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia Coli Sequence Type 405 of Clinical Origin." Antimicrobial Agents and Chemotherapy, vol. 64, no. 6, 2020.
Wang CH, Siu LK, Chang FY, et al. A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin. Antimicrob Agents Chemother. 2020;64(6).
Wang, C. H., Siu, L. K., Chang, F. Y., Tsai, Y. K., Lin, Y. T., Chiu, S. K., Huang, L. Y., & Lin, J. C. (2020). A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin. Antimicrobial Agents and Chemotherapy, 64(6). https://doi.org/10.1128/AAC.00220-20
Wang CH, et al. A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia Coli Sequence Type 405 of Clinical Origin. Antimicrob Agents Chemother. 2020 05 21;64(6) PubMed PMID: 32284375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin. AU - Wang,Ching-Hsun, AU - Siu,L Kristopher, AU - Chang,Feng-Yee, AU - Tsai,Yu-Kuo, AU - Lin,Yi-Tsung, AU - Chiu,Sheng-Kang, AU - Huang,Li-Yueh, AU - Lin,Jung-Chung, Y1 - 2020/05/21/ PY - 2020/02/05/received PY - 2020/04/04/accepted PY - 2020/11/21/pmc-release PY - 2020/4/15/pubmed PY - 2020/4/15/medline PY - 2020/4/15/entrez KW - Escherichia coli KW - carbapenem KW - colistin KW - resistance JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 64 IS - 6 N2 - We report the first clinical Escherichia coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, Δ6-11 (RPISLR), in pmrB that contributes to colistin resistance was verified using recombinant DNA techniques. Although being less fit than the wild-type (WT) strain or EC3000 revertant (chromosomal replacement of WT pmrB in EC3000), a portion of serially passaged EC3000 strains preserving colistin resistance without selective pressure raises the concern for further spread. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/32284375/A_Novel_Deletion_Mutation_in_pmrB_Contributes_to_Concurrent_Colistin_Resistance_in_Carbapenem-Resistant_Escherichia_coli_Sequence_Type_405_of_Clinical_Origin L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=32284375 DB - PRIME DP - Unbound Medicine ER -
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