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Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption.
Scand J Gastroenterol. 2020 May; 55(5):615-620.SJ

Abstract

Objective: To analyze the incidence of acute alcoholic pancreatitis and of severe alcoholic liver disease (ALD) and its association with per capita alcohol consumption with identification of both alcoholic cirrhosis (AC) and severe alcoholic hepatitis (AH), in a population-based setting.Methods: A search was undertaken in diagnoses database for diagnostic codes in order to find patients hospitalized with incident acute alcoholic pancreatitis (AP) and alcoholic liver disease in Iceland in 2001-2015. Diagnoses were verified in all patients who were retrospectively reviewed. Those with ALD had either AC or AH. Alcohol sales during the study period were obtained from Statistics Iceland.Results: Overall, 273 patients with acute AP, mean age at diagnosis 50 (14) years, 74% males and 159 patients with ALD, mean age 57 (11) years, 73% males, were identified. Mean per capita alcohol consumption was 6.95 (0.4) liters and increased by 21% over the study period. The annual incidence of AP increased from 4.2 per 100.000 to 9.5 and ALD from 1.6 to 6.1 per 100.000. Trend analysis showed a significant annual increase of 7% (RR 1.07, 95%CI 1.04-1.10) for AP and an annual increase of 10.5% (RR 1.10, 95%CI 1.06-1.15) for ALD. The increase was only significant in males.Conclusions: Increase per capita alcohol consumption over a 15 year study period was associated with an increase in the incidence of severe alcoholic liver disease and alcohol-related acute pancreatitis in males but not in females.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hauksson K
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.
Arnardottir M
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.
Agustsson AS
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.
Magnusdottir BA
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.
Baldursdottir MB
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Lund SH
Decode Genetics, Reykjavik, Iceland, Copenhagen, Denmark.
Kalaitzakis E
Digestive Disease Center, Copenhagen University Hospital/Herlev, University of Copenhagen, Copenhagen, Denmark.
Björnsson ES
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

MeSH

Acute DiseaseAdultAlcohol DrinkingFemaleHepatitis, AlcoholicHumansIcelandIncidenceLiver Cirrhosis, AlcoholicMaleMiddle AgedPancreatitis, AlcoholicRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32289240

Citation

Hauksson, Kristjan, et al. "Increase in the Incidence of Alcoholic Pancreatitis and Alcoholic Liver Disease in Iceland: Impact of Per Capita Alcohol Consumption." Scandinavian Journal of Gastroenterology, vol. 55, no. 5, 2020, pp. 615-620.
Hauksson K, Arnardottir M, Agustsson AS, et al. Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption. Scand J Gastroenterol. 2020;55(5):615-620.
Hauksson, K., Arnardottir, M., Agustsson, A. S., Magnusdottir, B. A., Baldursdottir, M. B., Lund, S. H., Kalaitzakis, E., & Björnsson, E. S. (2020). Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption. Scandinavian Journal of Gastroenterology, 55(5), 615-620. https://doi.org/10.1080/00365521.2020.1751874
Hauksson K, et al. Increase in the Incidence of Alcoholic Pancreatitis and Alcoholic Liver Disease in Iceland: Impact of Per Capita Alcohol Consumption. Scand J Gastroenterol. 2020;55(5):615-620. PubMed PMID: 32289240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption. AU - Hauksson,Kristjan, AU - Arnardottir,Margret, AU - Agustsson,Arnar S, AU - Magnusdottir,Berglind A, AU - Baldursdottir,Maria B, AU - Lund,Sigrun H, AU - Kalaitzakis,Evangelos, AU - Björnsson,Einar S, Y1 - 2020/04/14/ PY - 2020/4/15/pubmed PY - 2021/6/29/medline PY - 2020/4/15/entrez KW - Acute pancreatitis KW - alcohol KW - alcoholic liver disease KW - incidence SP - 615 EP - 620 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 55 IS - 5 N2 - Objective: To analyze the incidence of acute alcoholic pancreatitis and of severe alcoholic liver disease (ALD) and its association with per capita alcohol consumption with identification of both alcoholic cirrhosis (AC) and severe alcoholic hepatitis (AH), in a population-based setting.Methods: A search was undertaken in diagnoses database for diagnostic codes in order to find patients hospitalized with incident acute alcoholic pancreatitis (AP) and alcoholic liver disease in Iceland in 2001-2015. Diagnoses were verified in all patients who were retrospectively reviewed. Those with ALD had either AC or AH. Alcohol sales during the study period were obtained from Statistics Iceland.Results: Overall, 273 patients with acute AP, mean age at diagnosis 50 (14) years, 74% males and 159 patients with ALD, mean age 57 (11) years, 73% males, were identified. Mean per capita alcohol consumption was 6.95 (0.4) liters and increased by 21% over the study period. The annual incidence of AP increased from 4.2 per 100.000 to 9.5 and ALD from 1.6 to 6.1 per 100.000. Trend analysis showed a significant annual increase of 7% (RR 1.07, 95%CI 1.04-1.10) for AP and an annual increase of 10.5% (RR 1.10, 95%CI 1.06-1.15) for ALD. The increase was only significant in males.Conclusions: Increase per capita alcohol consumption over a 15 year study period was associated with an increase in the incidence of severe alcoholic liver disease and alcohol-related acute pancreatitis in males but not in females. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/32289240/Increase_in_the_incidence_of_alcoholic_pancreatitis_and_alcoholic_liver_disease_in_Iceland:_impact_of_per_capita_alcohol_consumption_ DB - PRIME DP - Unbound Medicine ER -