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The evidence of SARS-CoV-2 infection on ocular surface.
Ocul Surf. 2020 07; 18(3):360-362.OS

Abstract

This is a cross-sectional study of patients who received a COVID-19 diagnosis between December 30, 2019 and February 7, 2020 at Tongji Hospital. A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. Patients had a mean [SD] gestational age of 57.63 [14.90] years. Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) were confirmed to have COVID-19 by laboratory diagnosis with a SARS-CoV-2 RT-PCR assay. Only two patients (2.78%) with conjunctivitis were identified from 72 patients with a laboratory confirmed COVID-19. Of those two patients, SARS-CoV-2 RNA fragments were found in ocular discharges by SARS-CoV-2 RT-PCR in only one patient. Our findings suspect the incidence of SARS-CoV-2 infection through the ocular surface is extremely low, while the nosocomial infection of SARS-CoV-2 through the eyes after occupational exposure is a potential route. To lower the SARS-CoV-2 nosocomial infection, all health care professionals should wear protective goggles. The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-CoV-2.

Authors+Show Affiliations

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: eyechen@aliyun.com.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: sunxufang2016@163.com.

Pub Type(s)

Editorial
Research Support, Non-U.S. Gov't
Comment

Language

eng

PubMed ID

32289466

Citation

Zhang, Xian, et al. "The Evidence of SARS-CoV-2 Infection On Ocular Surface." The Ocular Surface, vol. 18, no. 3, 2020, pp. 360-362.
Zhang X, Chen X, Chen L, et al. The evidence of SARS-CoV-2 infection on ocular surface. Ocul Surf. 2020;18(3):360-362.
Zhang, X., Chen, X., Chen, L., Deng, C., Zou, X., Liu, W., Yu, H., Chen, B., & Sun, X. (2020). The evidence of SARS-CoV-2 infection on ocular surface. The Ocular Surface, 18(3), 360-362. https://doi.org/10.1016/j.jtos.2020.03.010
Zhang X, et al. The Evidence of SARS-CoV-2 Infection On Ocular Surface. Ocul Surf. 2020;18(3):360-362. PubMed PMID: 32289466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The evidence of SARS-CoV-2 infection on ocular surface. AU - Zhang,Xian, AU - Chen,Xuhui, AU - Chen,Liwen, AU - Deng,Chaohua, AU - Zou,Xiaojing, AU - Liu,Weiyong, AU - Yu,Huimin, AU - Chen,Bo, AU - Sun,Xufang, Y1 - 2020/04/11/ PY - 2020/02/28/received PY - 2020/03/15/revised PY - 2020/03/19/accepted PY - 2020/4/15/pubmed PY - 2020/6/9/medline PY - 2020/4/15/entrez KW - COVID-19 KW - Conjunctival swab KW - Ocularsurface KW - Reverse-transcriptase-polymerase-chain-reaction KW - SARS-CoV-2 KW - Transmission route SP - 360 EP - 362 JF - The ocular surface JO - Ocul Surf VL - 18 IS - 3 N2 - This is a cross-sectional study of patients who received a COVID-19 diagnosis between December 30, 2019 and February 7, 2020 at Tongji Hospital. A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. Patients had a mean [SD] gestational age of 57.63 [14.90] years. Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) were confirmed to have COVID-19 by laboratory diagnosis with a SARS-CoV-2 RT-PCR assay. Only two patients (2.78%) with conjunctivitis were identified from 72 patients with a laboratory confirmed COVID-19. Of those two patients, SARS-CoV-2 RNA fragments were found in ocular discharges by SARS-CoV-2 RT-PCR in only one patient. Our findings suspect the incidence of SARS-CoV-2 infection through the ocular surface is extremely low, while the nosocomial infection of SARS-CoV-2 through the eyes after occupational exposure is a potential route. To lower the SARS-CoV-2 nosocomial infection, all health care professionals should wear protective goggles. The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-CoV-2. SN - 1937-5913 UR - https://www.unboundmedicine.com/medline/citation/32289466/The_evidence_of_SARS_CoV_2_infection_on_ocular_surface_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-0124(20)30065-3 DB - PRIME DP - Unbound Medicine ER -