Tags

Type your tag names separated by a space and hit enter

Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta.
Clin Cardiol. 1988 Sep; 11(9):639-41.CC

Abstract

Paradoxical hypertension is a relatively common complication of surgical repair of coarctation of the aorta. An early phase of systolic hypertension has been ascribed to elevated levels of norepinephrine. Activation of the renin-angiotensin system from sympathetic stimulation has been implicated in a later phase of systolic and diastolic hypertension that can result in mesenteric arteritis. The use of a rapidly acting, titratable intravenous alpha- and beta-adrenergic blocker, such as labetalol hydrochloride, addresses both of these neurohormonal mechanisms. In the intravenous form, it would appear to be an excellent choice for the management of early postoperative hypertension and it can be converted to the oral form in cases of persistent hypertension. We report for the first time the use of labetalol in two young patients for the control of paradoxical hypertension following coarctation repair.

Authors+Show Affiliations

Bojar RM
Department of Cardiothoracic Surgery, New England Medical Center Hospitals, Boston, Massachusetts 02111.
Weiner B
No affiliation info available
Cleveland RJ
No affiliation info available

MeSH

AdolescentAortic CoarctationHumansHypertensionInfusions, IntravenousLabetalolMalePostoperative Complications

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3229019

Citation

Bojar, R M., et al. "Intravenous Labetalol for the Control of Hypertension Following Repair of Coarctation of the Aorta." Clinical Cardiology, vol. 11, no. 9, 1988, pp. 639-41.
Bojar RM, Weiner B, Cleveland RJ. Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta. Clin Cardiol. 1988;11(9):639-41.
Bojar, R. M., Weiner, B., & Cleveland, R. J. (1988). Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta. Clinical Cardiology, 11(9), 639-41.
Bojar RM, Weiner B, Cleveland RJ. Intravenous Labetalol for the Control of Hypertension Following Repair of Coarctation of the Aorta. Clin Cardiol. 1988;11(9):639-41. PubMed PMID: 3229019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta. AU - Bojar,R M, AU - Weiner,B, AU - Cleveland,R J, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 639 EP - 41 JF - Clinical cardiology JO - Clin Cardiol VL - 11 IS - 9 N2 - Paradoxical hypertension is a relatively common complication of surgical repair of coarctation of the aorta. An early phase of systolic hypertension has been ascribed to elevated levels of norepinephrine. Activation of the renin-angiotensin system from sympathetic stimulation has been implicated in a later phase of systolic and diastolic hypertension that can result in mesenteric arteritis. The use of a rapidly acting, titratable intravenous alpha- and beta-adrenergic blocker, such as labetalol hydrochloride, addresses both of these neurohormonal mechanisms. In the intravenous form, it would appear to be an excellent choice for the management of early postoperative hypertension and it can be converted to the oral form in cases of persistent hypertension. We report for the first time the use of labetalol in two young patients for the control of paradoxical hypertension following coarctation repair. SN - 0160-9289 UR - https://www.unboundmedicine.com/medline/citation/3229019/Intravenous_labetalol_for_the_control_of_hypertension_following_repair_of_coarctation_of_the_aorta_ DB - PRIME DP - Unbound Medicine ER -