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[Effects of lycopene on metabolism of glycolipid and inflammation in non-alcoholic fatty liver disease rats].
Wei Sheng Yan Jiu. 2020 Mar; 49(2):254-271.WS

Abstract

OBJECTIVE

To investigate the effects of lycopene on metabolism of glycolipid and inflammation in rats with non-alcoholic fatty liver disease.

METHODS

According to body weight, sixty male Sprague-Dawley rats were randomly divided into control group, non-alcoholic fatty liver model group, 20, 60 mg/kg lycopene intervention groups, with 15 rats in each group. The control group was fed normal diet, and the other 3 groups were fed high-fat and high-fructose diet for 4 weeks to establish the model of non-alcoholic fatty liver disease. After modeling, the intervention groups were fed lycopene of different doses by gavage. After 8 weeks of continuous feeding, the rats were sacrificed, the body weight and liver weight were weighed, and the liver index was calculated. Hematoxylin-eosin staining was used to observe the morphological changes of liver tissue. Serum was collected, fasting blood glucose(FBG), fasting insulin(INS), and insulin resistance index(HOMA-IR) were calculated; Liver function indicators alanine aminotransferase(ALT), aspartate aminotransferase(AST) were measured; Serum triglycerides(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C) and levels of inflammatory cytokines interleukin-6(IL-6), interleukin-18(IL-18) and interleukin-1β(IL-1β) were measured.

RESULTS

Compared with the control group, the liver weight and liver index in the model group increased by 27% and 24%, respectively; And steatosis occurred in the liver tissue; The levels of serum ALT, TG, TC, LDL-C, IL-6, IL-1β were significantly increased, the level of serum HDL-C was significantly decreased(P<0. 05). Compared with the model group, liver weight, liver index, levels of serum ALT, TG, FBG, IL-6 and IL-1β were significantly lower in the 20, 60 mg/kg lycopene intervention groups(P<0. 05), the INS and HOMA-IR index showed a downward trend; Liver tissue lesions were reduced to different degrees, and the effect was more significant in the 60 mg/kg lycopene group.

CONCLUSION

Lycopene can improve non-alcoholic fatty liver disease by regulating glycolipid metabolism and reducing levels of inflammatory cytokines in rats.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

32290942

Citation

Zhang, Peipei, et al. "[Effects of Lycopene On Metabolism of Glycolipid and Inflammation in Non-alcoholic Fatty Liver Disease Rats]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 49, no. 2, 2020, pp. 254-271.
Zhang P, Li J, Li M, et al. [Effects of lycopene on metabolism of glycolipid and inflammation in non-alcoholic fatty liver disease rats]. Wei Sheng Yan Jiu. 2020;49(2):254-271.
Zhang, P., Li, J., Li, M., Sui, Y., Zhou, Y., & Sun, Y. (2020). [Effects of lycopene on metabolism of glycolipid and inflammation in non-alcoholic fatty liver disease rats]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 49(2), 254-271. https://doi.org/10.19813/j.cnki.weishengyanjiu.2020.02.015
Zhang P, et al. [Effects of Lycopene On Metabolism of Glycolipid and Inflammation in Non-alcoholic Fatty Liver Disease Rats]. Wei Sheng Yan Jiu. 2020;49(2):254-271. PubMed PMID: 32290942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of lycopene on metabolism of glycolipid and inflammation in non-alcoholic fatty liver disease rats]. AU - Zhang,Peipei, AU - Li,Jingxian, AU - Li,Mengli, AU - Sui,Yuan, AU - Zhou,Yuhao, AU - Sun,Yongye, PY - 2020/4/16/entrez PY - 2020/4/16/pubmed PY - 2020/4/16/medline KW - glycolipid metabolism KW - inflammatory cytokines KW - lycopene KW - non-alcoholic fatty liver disease SP - 254 EP - 271 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 49 IS - 2 N2 - OBJECTIVE: To investigate the effects of lycopene on metabolism of glycolipid and inflammation in rats with non-alcoholic fatty liver disease. METHODS: According to body weight, sixty male Sprague-Dawley rats were randomly divided into control group, non-alcoholic fatty liver model group, 20, 60 mg/kg lycopene intervention groups, with 15 rats in each group. The control group was fed normal diet, and the other 3 groups were fed high-fat and high-fructose diet for 4 weeks to establish the model of non-alcoholic fatty liver disease. After modeling, the intervention groups were fed lycopene of different doses by gavage. After 8 weeks of continuous feeding, the rats were sacrificed, the body weight and liver weight were weighed, and the liver index was calculated. Hematoxylin-eosin staining was used to observe the morphological changes of liver tissue. Serum was collected, fasting blood glucose(FBG), fasting insulin(INS), and insulin resistance index(HOMA-IR) were calculated; Liver function indicators alanine aminotransferase(ALT), aspartate aminotransferase(AST) were measured; Serum triglycerides(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C) and levels of inflammatory cytokines interleukin-6(IL-6), interleukin-18(IL-18) and interleukin-1β(IL-1β) were measured. RESULTS: Compared with the control group, the liver weight and liver index in the model group increased by 27% and 24%, respectively; And steatosis occurred in the liver tissue; The levels of serum ALT, TG, TC, LDL-C, IL-6, IL-1β were significantly increased, the level of serum HDL-C was significantly decreased(P<0. 05). Compared with the model group, liver weight, liver index, levels of serum ALT, TG, FBG, IL-6 and IL-1β were significantly lower in the 20, 60 mg/kg lycopene intervention groups(P<0. 05), the INS and HOMA-IR index showed a downward trend; Liver tissue lesions were reduced to different degrees, and the effect was more significant in the 60 mg/kg lycopene group. CONCLUSION: Lycopene can improve non-alcoholic fatty liver disease by regulating glycolipid metabolism and reducing levels of inflammatory cytokines in rats. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/32290942/[Effects_of_lycopene_on_metabolism_of_glycolipid_and_inflammation_in_non_alcoholic_fatty_liver_disease_rats]_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL18-4 DB - PRIME DP - Unbound Medicine ER -