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On the Alert for Cytokine Storm: Immunopathology in COVID-19.
Arthritis Rheumatol. 2020 07; 72(7):1059-1063.AR

Abstract

Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.

Authors+Show Affiliations

Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.Temple University Hospital and Lewis Katz School of Medicine, Philadelphia, Pennsylvania.University of Minnesota Medical Center and University of Minnesota School of Medicine, Minneapolis.Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.Icahn School of Medicine at Mount Sinai, New York, New York.Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.Ospedale Pediatrico Bambino Gesù, Rome, Italy.Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.Children's of Alabama, University of Alabama at Birmingham, Birmingham.Boston Children's Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32293098

Citation

Henderson, Lauren A., et al. "On the Alert for Cytokine Storm: Immunopathology in COVID-19." Arthritis & Rheumatology (Hoboken, N.J.), vol. 72, no. 7, 2020, pp. 1059-1063.
Henderson LA, Canna SW, Schulert GS, et al. On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis Rheumatol. 2020;72(7):1059-1063.
Henderson, L. A., Canna, S. W., Schulert, G. S., Volpi, S., Lee, P. Y., Kernan, K. F., Caricchio, R., Mahmud, S., Hazen, M. M., Halyabar, O., Hoyt, K. J., Han, J., Grom, A. A., Gattorno, M., Ravelli, A., De Benedetti, F., Behrens, E. M., Cron, R. Q., & Nigrovic, P. A. (2020). On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis & Rheumatology (Hoboken, N.J.), 72(7), 1059-1063. https://doi.org/10.1002/art.41285
Henderson LA, et al. On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis Rheumatol. 2020;72(7):1059-1063. PubMed PMID: 32293098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the Alert for Cytokine Storm: Immunopathology in COVID-19. AU - Henderson,Lauren A, AU - Canna,Scott W, AU - Schulert,Grant S, AU - Volpi,Stefano, AU - Lee,Pui Y, AU - Kernan,Kate F, AU - Caricchio,Roberto, AU - Mahmud,Shawn, AU - Hazen,Melissa M, AU - Halyabar,Olha, AU - Hoyt,Kacie J, AU - Han,Joseph, AU - Grom,Alexei A, AU - Gattorno,Marco, AU - Ravelli,Angelo, AU - De Benedetti,Fabrizio, AU - Behrens,Edward M, AU - Cron,Randy Q, AU - Nigrovic,Peter A, Y1 - 2020/05/10/ PY - 2020/03/31/received PY - 2020/04/07/accepted PY - 2020/4/16/pubmed PY - 2020/7/15/medline PY - 2020/4/16/entrez SP - 1059 EP - 1063 JF - Arthritis & rheumatology (Hoboken, N.J.) JO - Arthritis Rheumatol VL - 72 IS - 7 N2 - Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19. SN - 2326-5205 UR - https://www.unboundmedicine.com/medline/citation/32293098/On_the_Alert_for_Cytokine_Storm:_Immunopathology_in_COVID_19_ L2 - https://doi.org/10.1002/art.41285 DB - PRIME DP - Unbound Medicine ER -