Temporal dynamics in viral shedding and transmissibility of COVID-19.Nat Med. 2020 05; 26(5):672-675.NMed
Abstract
We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector-infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25-69%) of secondary cases were infected during the index cases' presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home. Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
32296168
Clinical Trial Links
Citation
He, Xi, et al. "Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19." Nature Medicine, vol. 26, no. 5, 2020, pp. 672-675.
He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26(5):672-675.
He, X., Lau, E. H. Y., Wu, P., Deng, X., Wang, J., Hao, X., Lau, Y. C., Wong, J. Y., Guan, Y., Tan, X., Mo, X., Chen, Y., Liao, B., Chen, W., Hu, F., Zhang, Q., Zhong, M., Wu, Y., Zhao, L., ... Leung, G. M. (2020). Temporal dynamics in viral shedding and transmissibility of COVID-19. Nature Medicine, 26(5), 672-675. https://doi.org/10.1038/s41591-020-0869-5
He X, et al. Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19. Nat Med. 2020;26(5):672-675. PubMed PMID: 32296168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Temporal dynamics in viral shedding and transmissibility of COVID-19.
AU - He,Xi,
AU - Lau,Eric H Y,
AU - Wu,Peng,
AU - Deng,Xilong,
AU - Wang,Jian,
AU - Hao,Xinxin,
AU - Lau,Yiu Chung,
AU - Wong,Jessica Y,
AU - Guan,Yujuan,
AU - Tan,Xinghua,
AU - Mo,Xiaoneng,
AU - Chen,Yanqing,
AU - Liao,Baolin,
AU - Chen,Weilie,
AU - Hu,Fengyu,
AU - Zhang,Qing,
AU - Zhong,Mingqiu,
AU - Wu,Yanrong,
AU - Zhao,Lingzhai,
AU - Zhang,Fuchun,
AU - Cowling,Benjamin J,
AU - Li,Fang,
AU - Leung,Gabriel M,
Y1 - 2020/04/15/
PY - 2020/03/15/received
PY - 2020/04/01/accepted
PY - 2020/4/17/pubmed
PY - 2020/5/19/medline
PY - 2020/4/17/entrez
SP - 672
EP - 675
JF - Nature medicine
JO - Nat Med
VL - 26
IS - 5
N2 - We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector-infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25-69%) of secondary cases were infected during the index cases' presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home. Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.
SN - 1546-170X
UR - https://www.unboundmedicine.com/medline/citation/32296168/full_citation
L2 - https://doi.org/10.1038/s41591-020-0869-5
DB - PRIME
DP - Unbound Medicine
ER -