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Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives.
Curr Top Med Chem. 2020; 20(13):1169-1194.CT

Abstract

BACKGROUND

Flavonoids, a group of natural dietary polyphenols, are known for their beneficial effects on human health. By virtue of their various pharmacological effects, like anti-oxidative, antiinflammatory, anti-carcinogenic and neuroprotective effects, flavonoids have now become an important component of herbal supplements, pharmaceuticals, medicinals and cosmetics. There has been enormous literature supporting neuroprotective effect of flavonoids. Recently their efficacy in various neurodegenerative diseases, like Alzheimer's disease and Parkinson diseases, has received particular attention.

OBJECTIVE

The mechanism of flavanoids neuroprotection might include antioxidant, antiapoptotic, antineuroinflammatory and modulation of various cellular and intracellular targets. In in-vivo systems, before reaching to brain, they have to cross barriers like extensive first pass metabolism, intestinal barrier and ultimately blood brain barrier. Different flavonoids have varied pharmacokinetic characteristics, which affect their pharmacodynamic profile. Therefore, brain accessibility of flavonoids is still debatable.

METHODS

This review emphasized on current trends of research and development on flavonoids, especially in neurodegenerative diseases, possible challenges and strategies to encounter using novel drug delivery system.

RESULTS

Various flavonoids have elicited their therapeutic potential against neurodegenerative diseases, however by using nanotechnology and novel drug delivery systems, the bioavailability of favonoids could be enhanced.

CONCLUSION

This study bridges a significant opinion on medicinal chemistry, ethanopharmacology and new drug delivery research regarding use of flavonoids in management of neurodegeneration.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32297582

Citation

Maan, Gagandeep, et al. "Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives." Current Topics in Medicinal Chemistry, vol. 20, no. 13, 2020, pp. 1169-1194.
Maan G, Sikdar B, Kumar A, et al. Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives. Curr Top Med Chem. 2020;20(13):1169-1194.
Maan, G., Sikdar, B., Kumar, A., Shukla, R., & Mishra, A. (2020). Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives. Current Topics in Medicinal Chemistry, 20(13), 1169-1194. https://doi.org/10.2174/1568026620666200416085330
Maan G, et al. Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives. Curr Top Med Chem. 2020;20(13):1169-1194. PubMed PMID: 32297582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives. AU - Maan,Gagandeep, AU - Sikdar,Biplab, AU - Kumar,Ashish, AU - Shukla,Rahul, AU - Mishra,Awanish, PY - 2020/02/07/received PY - 2020/03/13/revised PY - 2020/03/13/accepted PY - 2020/4/17/pubmed PY - 2021/1/26/medline PY - 2020/4/17/entrez KW - Bioavailability KW - Flavonoids KW - Nanoformulations KW - Neurodegenerative diseases KW - Neuroprotection KW - New drug delivery systems. SP - 1169 EP - 1194 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 20 IS - 13 N2 - BACKGROUND: Flavonoids, a group of natural dietary polyphenols, are known for their beneficial effects on human health. By virtue of their various pharmacological effects, like anti-oxidative, antiinflammatory, anti-carcinogenic and neuroprotective effects, flavonoids have now become an important component of herbal supplements, pharmaceuticals, medicinals and cosmetics. There has been enormous literature supporting neuroprotective effect of flavonoids. Recently their efficacy in various neurodegenerative diseases, like Alzheimer's disease and Parkinson diseases, has received particular attention. OBJECTIVE: The mechanism of flavanoids neuroprotection might include antioxidant, antiapoptotic, antineuroinflammatory and modulation of various cellular and intracellular targets. In in-vivo systems, before reaching to brain, they have to cross barriers like extensive first pass metabolism, intestinal barrier and ultimately blood brain barrier. Different flavonoids have varied pharmacokinetic characteristics, which affect their pharmacodynamic profile. Therefore, brain accessibility of flavonoids is still debatable. METHODS: This review emphasized on current trends of research and development on flavonoids, especially in neurodegenerative diseases, possible challenges and strategies to encounter using novel drug delivery system. RESULTS: Various flavonoids have elicited their therapeutic potential against neurodegenerative diseases, however by using nanotechnology and novel drug delivery systems, the bioavailability of favonoids could be enhanced. CONCLUSION: This study bridges a significant opinion on medicinal chemistry, ethanopharmacology and new drug delivery research regarding use of flavonoids in management of neurodegeneration. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/32297582/Role_of_Flavonoids_in_Neurodegenerative_Diseases:_Limitations_and_Future_Perspectives_ L2 - http://www.eurekaselect.com/180934/article DB - PRIME DP - Unbound Medicine ER -