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The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer.
Jpn J Clin Oncol. 2020 Apr 07; 50(4):446-455.JJ

Abstract

OBJECTIVE

The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer.

METHODS

Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC).

RESULTS

c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan-Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046).

CONCLUSIONS

Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis.

Authors+Show Affiliations

Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32297641

Citation

Pan, Weiyu, et al. "The Prognostic Role of c-MYC Amplification in Schistosomiasis-associated Colorectal Cancer." Japanese Journal of Clinical Oncology, vol. 50, no. 4, 2020, pp. 446-455.
Pan W, Wang W, Huang J, et al. The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer. Jpn J Clin Oncol. 2020;50(4):446-455.
Pan, W., Wang, W., Huang, J., Lu, K., Huang, S., Jiang, D., Bu, D., Liu, J., Jing, H., Yao, J., & Hou, Y. (2020). The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer. Japanese Journal of Clinical Oncology, 50(4), 446-455. https://doi.org/10.1093/jjco/hyz210
Pan W, et al. The Prognostic Role of c-MYC Amplification in Schistosomiasis-associated Colorectal Cancer. Jpn J Clin Oncol. 2020 Apr 7;50(4):446-455. PubMed PMID: 32297641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer. AU - Pan,Weiyu, AU - Wang,Weixia, AU - Huang,Jie, AU - Lu,Kui, AU - Huang,Sinian, AU - Jiang,Dongxian, AU - Bu,Dacheng, AU - Liu,Jing, AU - Jing,Hongyan, AU - Yao,Junxia, AU - Hou,Yingyong, PY - 2019/07/31/received PY - 2019/12/15/revised PY - 2019/12/20/accepted PY - 2020/4/17/entrez PY - 2020/4/17/pubmed PY - 2020/6/27/medline KW - Schistosoma japonicum KW - c-MYC KW - colorectal cancer KW - gene amplification KW - prognosis SP - 446 EP - 455 JF - Japanese journal of clinical oncology JO - Jpn. J. Clin. Oncol. VL - 50 IS - 4 N2 - OBJECTIVE: The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer. METHODS: Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC). RESULTS: c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan-Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046). CONCLUSIONS: Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis. SN - 1465-3621 UR - https://www.unboundmedicine.com/medline/citation/32297641/The_prognostic_role_of_c_MYC_amplification_in_schistosomiasis_associated_colorectal_cancer_ L2 - https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyz210 DB - PRIME DP - Unbound Medicine ER -