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Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients.
Br J Haematol. 2020 05; 189(3):428-437.BJ

Abstract

We explored the relationships between lymphocyte subsets, cytokines, pulmonary inflammation index (PII) and disease evolution in patients with (corona virus disease 2019) COVID-19. A total of 123 patients with COVID-19 were divided into mild and severe groups. Lymphocyte subsets and cytokines were detected on the first day of hospital admission and lung computed tomography results were quantified by PII. Difference analysis and correlation analysis were performed on the two groups. A total of 102 mild and 21 severe patients were included in the analysis. There were significant differences in cluster of differentiation 4 (CD4+ T), cluster of differentiation 8 (CD8+ T), interleukin 6 (IL-6), interleukin 10 (IL-10) and PII between the two groups. There were significant positive correlations between CD4+ T and CD8+ T, IL-6 and IL-10 in the mild group (r2 = 0·694, r 2 = 0·633, respectively; P < 0·01). After 'five-in-one' treatment, all patients were discharged with the exception of the four who died. Higher survival rates occurred in the mild group and in those with IL-6 within normal values. CD4+ T, CD8+ T, IL-6, IL-10 and PII can be used as indicators of disease evolution, and the PII can be used as an independent indicator for disease progression of COVID-19.

Authors+Show Affiliations

Chongqing University, Three Gorges Hospital, Chongqing, China. Pharmaceutical Department of Chongqing Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Quality Control Department of Chongqing Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Neurosurgery of Chongqing Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Hematology, Chongqing, Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Endocrinology, Chongqing, Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Endocrinology, Chongqing, Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Research and Foreign Affairs Department of Chongqing Three Gorges Central Hospital, Chongqing, China.Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Cardiology, Chongqing Three Gorges Center Hospital, Chongqing, China.School of Mathematics and Statistics, Chongqing University, Chongqing, China.College of Basic Medicine, Qingdao University, Qingdao, Shandong, China. Qingdao Raisecare Biotechnology Co., Ltd, Qingdao, Shandong, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Infectious Diseases, Chongqing Three Gorges Center Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Hematology, Chongqing, Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Hematology, Chongqing, Three Gorges Central Hospital, Chongqing, China.Chongqing University, Three Gorges Hospital, Chongqing, China. Department of Radiology, Chongqing Three Gorges Central Hospital, Chongqing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32297671

Citation

Wan, Suxin, et al. "Relationships Among Lymphocyte Subsets, Cytokines, and the Pulmonary Inflammation Index in Coronavirus (COVID-19) Infected Patients." British Journal of Haematology, vol. 189, no. 3, 2020, pp. 428-437.
Wan S, Yi Q, Fan S, et al. Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. Br J Haematol. 2020;189(3):428-437.
Wan, S., Yi, Q., Fan, S., Lv, J., Zhang, X., Guo, L., Lang, C., Xiao, Q., Xiao, K., Yi, Z., Qiang, M., Xiang, J., Zhang, B., Chen, Y., & Gao, C. (2020). Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. British Journal of Haematology, 189(3), 428-437. https://doi.org/10.1111/bjh.16659
Wan S, et al. Relationships Among Lymphocyte Subsets, Cytokines, and the Pulmonary Inflammation Index in Coronavirus (COVID-19) Infected Patients. Br J Haematol. 2020;189(3):428-437. PubMed PMID: 32297671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. AU - Wan,Suxin, AU - Yi,Qingjie, AU - Fan,Shibing, AU - Lv,Jinglong, AU - Zhang,Xianxiang, AU - Guo,Lian, AU - Lang,Chunhui, AU - Xiao,Qing, AU - Xiao,Kaihu, AU - Yi,Zhengjun, AU - Qiang,Mao, AU - Xiang,Jianglin, AU - Zhang,Bangshuo, AU - Chen,Yongping, AU - Gao,Cailiang, Y1 - 2020/04/20/ PY - 2020/02/24/received PY - 2020/03/22/accepted PY - 2020/4/17/pubmed PY - 2020/5/1/medline PY - 2020/4/17/entrez KW - coronavirus infected disease KW - cytokines KW - disease classification KW - lymphocyte subsets KW - pulmonary inflammatory index SP - 428 EP - 437 JF - British journal of haematology JO - Br J Haematol VL - 189 IS - 3 N2 - We explored the relationships between lymphocyte subsets, cytokines, pulmonary inflammation index (PII) and disease evolution in patients with (corona virus disease 2019) COVID-19. A total of 123 patients with COVID-19 were divided into mild and severe groups. Lymphocyte subsets and cytokines were detected on the first day of hospital admission and lung computed tomography results were quantified by PII. Difference analysis and correlation analysis were performed on the two groups. A total of 102 mild and 21 severe patients were included in the analysis. There were significant differences in cluster of differentiation 4 (CD4+ T), cluster of differentiation 8 (CD8+ T), interleukin 6 (IL-6), interleukin 10 (IL-10) and PII between the two groups. There were significant positive correlations between CD4+ T and CD8+ T, IL-6 and IL-10 in the mild group (r2 = 0·694, r 2 = 0·633, respectively; P < 0·01). After 'five-in-one' treatment, all patients were discharged with the exception of the four who died. Higher survival rates occurred in the mild group and in those with IL-6 within normal values. CD4+ T, CD8+ T, IL-6, IL-10 and PII can be used as indicators of disease evolution, and the PII can be used as an independent indicator for disease progression of COVID-19. SN - 1365-2141 UR - https://www.unboundmedicine.com/medline/citation/32297671/Relationships_among_lymphocyte_subsets_cytokines_and_the_pulmonary_inflammation_index_in_coronavirus__COVID_19__infected_patients_ L2 - https://doi.org/10.1111/bjh.16659 DB - PRIME DP - Unbound Medicine ER -