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COVID-2019: update on epidemiology, disease spread and management.
Monaldi Arch Chest Dis. 2020 Apr 16; 90(1)MA

Abstract

With each passing day, more cases of Coronavirus disease (COVID-2019) are being detected and unfortunately the fear of novel corona virus 2019 (2019-nCoV) becoming a pandemic disease has come true. Constant efforts at individual, national, and international level are being made in order to understand the genomics, hosts, modes of transmission and epidemiological link of nCoV-2019. As of now, whole genome sequence of the newly discovered coronavirus has already been decoded. Genomic characterization nCoV-2019 have shown close homology with bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21. Structural analysis of the receptor binding site has confirmed that 2019-nCoV binds with the same ACE 2 receptor protein as human SARS virus. Compared to the previous coronavirus outbreaks, the overall mortality rate is relatively low for COVID-2019 (2-3%). Suspected cases must be quarantined till their test comes positive or they clear infection. At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. Many other antiviral agents and vaccines are being tested but most of them are in phase I or II and hence unlikely to be of any benefit immediately with regards to current outbreak. Hence, the standard infection control techniques and preventive steps for healthy individuals and supportive care for the confirmed cases is the best available strategy to deal with current viral outbreak. .

Authors+Show Affiliations

Department of Internal medicine, Saint Vincent Hospital, Worcester, Massachusetts, United States of America, 01608. Kamalkant.Sahu@stvincenthospital.com.Department of Internal medicine, Saint Vincent Hospital, Worcester, Massachusetts, United States of America, 01608. Ajaybalasore@gmail.com.Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester. manavamos@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32297723

Citation

Sahu, Kamal Kant, et al. "COVID-2019: Update On Epidemiology, Disease Spread and Management." Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace, vol. 90, no. 1, 2020.
Sahu KK, Mishra AK, Lal A. COVID-2019: update on epidemiology, disease spread and management. Monaldi Arch Chest Dis. 2020;90(1).
Sahu, K. K., Mishra, A. K., & Lal, A. (2020). COVID-2019: update on epidemiology, disease spread and management. Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace, 90(1). https://doi.org/10.4081/monaldi.2020.1292
Sahu KK, Mishra AK, Lal A. COVID-2019: Update On Epidemiology, Disease Spread and Management. Monaldi Arch Chest Dis. 2020 Apr 16;90(1) PubMed PMID: 32297723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-2019: update on epidemiology, disease spread and management. AU - Sahu,Kamal Kant, AU - Mishra,Ajay Kumar, AU - Lal,Amos, Y1 - 2020/04/16/ PY - 2020/03/31/received PY - 2020/04/10/accepted PY - 2020/4/17/entrez PY - 2020/4/17/pubmed PY - 2020/4/21/medline JF - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace JO - Monaldi Arch Chest Dis VL - 90 IS - 1 N2 - With each passing day, more cases of Coronavirus disease (COVID-2019) are being detected and unfortunately the fear of novel corona virus 2019 (2019-nCoV) becoming a pandemic disease has come true. Constant efforts at individual, national, and international level are being made in order to understand the genomics, hosts, modes of transmission and epidemiological link of nCoV-2019. As of now, whole genome sequence of the newly discovered coronavirus has already been decoded. Genomic characterization nCoV-2019 have shown close homology with bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21. Structural analysis of the receptor binding site has confirmed that 2019-nCoV binds with the same ACE 2 receptor protein as human SARS virus. Compared to the previous coronavirus outbreaks, the overall mortality rate is relatively low for COVID-2019 (2-3%). Suspected cases must be quarantined till their test comes positive or they clear infection. At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. Many other antiviral agents and vaccines are being tested but most of them are in phase I or II and hence unlikely to be of any benefit immediately with regards to current outbreak. Hence, the standard infection control techniques and preventive steps for healthy individuals and supportive care for the confirmed cases is the best available strategy to deal with current viral outbreak. . SN - 1122-0643 UR - https://www.unboundmedicine.com/medline/citation/32297723/COVID_2019:_update_on_epidemiology_disease_spread_and_management_ L2 - https://doi.org/10.4081/monaldi.2020.1292 DB - PRIME DP - Unbound Medicine ER -