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Early diagnosis and treatment challenges of endodermal sinus tumors: A case report.
Case Rep Womens Health. 2020 Jul; 27:e00198.CR

Abstract

Background

Ovarian endodermal sinus tumors (ESTs) are rapidly growing and highly malignant tumors that respond well to chemotherapy. They can be difficult to diagnose and delayed diagnosis can worsen prognosis.

Case

We present the case of a 20-year-old woman with an EST initially misdiagnosed as a tubo-ovarian abscess who then experienced rapid progression within weeks of initial presentation and was subsequently found to have unresectable advanced stage disease.

Conclusion

ESTs are extremely aggressive and require prompt referral and early treatment with chemotherapy. Presenting symptoms of pain and a mass can lead to a broad range of differential diagnoses. In such patients, early consideration of tumor markers is warranted. This case report reviews the key aspects for prompt diagnosis and rapid treatment of these tumors, which significantly impacts the prognosis.

Authors+Show Affiliations

University of Cincinnati College of Medicine, Cincinnati, OH, United States.Division of Gynecologic Oncology, University of Cincinnati, Cincinnati, OH, United States.Division of Gynecologic Oncology, University of Cincinnati, Cincinnati, OH, United States.Division of Gynecologic Oncology, University of Cincinnati, Cincinnati, OH, United States.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32300538

Citation

Perry, Madeline F., et al. "Early Diagnosis and Treatment Challenges of Endodermal Sinus Tumors: a Case Report." Case Reports in Women's Health, vol. 27, 2020, pp. e00198.
Perry MF, Jackson AL, Herzog TJ, et al. Early diagnosis and treatment challenges of endodermal sinus tumors: A case report. Case Rep Womens Health. 2020;27:e00198.
Perry, M. F., Jackson, A. L., Herzog, T. J., & Billingsley, C. C. (2020). Early diagnosis and treatment challenges of endodermal sinus tumors: A case report. Case Reports in Women's Health, 27, e00198. https://doi.org/10.1016/j.crwh.2020.e00198
Perry MF, et al. Early Diagnosis and Treatment Challenges of Endodermal Sinus Tumors: a Case Report. Case Rep Womens Health. 2020;27:e00198. PubMed PMID: 32300538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early diagnosis and treatment challenges of endodermal sinus tumors: A case report. AU - Perry,Madeline F, AU - Jackson,Amanda L, AU - Herzog,Thomas J, AU - Billingsley,Caroline C, Y1 - 2020/04/03/ PY - 2020/03/02/received PY - 2020/03/30/revised PY - 2020/04/02/accepted PY - 2020/4/18/entrez PY - 2020/4/18/pubmed PY - 2020/4/18/medline KW - Bleomycin-etoposide-cisplatin chemotherapy KW - Differential KW - Endodermal sinus tumor KW - Germ cell tumor KW - Prognosis KW - Tubo-ovarian abscess SP - e00198 EP - e00198 JF - Case reports in women's health JO - Case Rep Womens Health VL - 27 N2 - Background: Ovarian endodermal sinus tumors (ESTs) are rapidly growing and highly malignant tumors that respond well to chemotherapy. They can be difficult to diagnose and delayed diagnosis can worsen prognosis. Case: We present the case of a 20-year-old woman with an EST initially misdiagnosed as a tubo-ovarian abscess who then experienced rapid progression within weeks of initial presentation and was subsequently found to have unresectable advanced stage disease. Conclusion: ESTs are extremely aggressive and require prompt referral and early treatment with chemotherapy. Presenting symptoms of pain and a mass can lead to a broad range of differential diagnoses. In such patients, early consideration of tumor markers is warranted. This case report reviews the key aspects for prompt diagnosis and rapid treatment of these tumors, which significantly impacts the prognosis. SN - 2214-9112 UR - https://www.unboundmedicine.com/medline/citation/32300538/Early_diagnosis_and_treatment_challenges_of_endodermal_sinus_tumors:_A_case_report. L2 - https://linkinghub.elsevier.com/retrieve/pii/S2214-9112(20)30028-X DB - PRIME DP - Unbound Medicine ER -
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