Tags

Type your tag names separated by a space and hit enter

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor.
Pharmacol Res. 2020 07; 157:104833.PR

Abstract

The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a negative regulator. Recently, ACE2 was identified as the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that is causing the pandemic of Coronavirus disease 2019 (COVID-19). Since SARS-CoV-2 must bind with ACE2 before entering the host cells in humans, the distribution and expression of ACE2 may be critical for the target organ of the SARS-CoV-2 infection. Moreover, accumulating evidence has demonstrated the implication of ACE2 in the pathological progression in tissue injury and several chronic diseases, ACE2 may also be essential in the progression and clinical outcomes of COVID-19. Therefore, we summarized the expression and activity of ACE2 in various physiological and pathological conditions, and discussed its potential implication in the susceptibility of SARS-CoV-2 infection and the progression and prognosis of COVID-19 patients in the current review.

Authors+Show Affiliations

Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, 210000, China; School of Medicine, Southeast University, Nanjing, 210000, China.Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, 210000, China.Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, 210000, China. Electronic address: yangly2018njmu@163.com.Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, 210000, China. Electronic address: yourannch@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32302706

Citation

Li, Yanwei, et al. "Physiological and Pathological Regulation of ACE2, the SARS-CoV-2 Receptor." Pharmacological Research, vol. 157, 2020, p. 104833.
Li Y, Zhou W, Yang L, et al. Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Pharmacol Res. 2020;157:104833.
Li, Y., Zhou, W., Yang, L., & You, R. (2020). Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Pharmacological Research, 157, 104833. https://doi.org/10.1016/j.phrs.2020.104833
Li Y, et al. Physiological and Pathological Regulation of ACE2, the SARS-CoV-2 Receptor. Pharmacol Res. 2020;157:104833. PubMed PMID: 32302706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. AU - Li,Yanwei, AU - Zhou,Wei, AU - Yang,Li, AU - You,Ran, Y1 - 2020/04/14/ PY - 2020/02/24/received PY - 2020/04/09/revised PY - 2020/04/10/accepted PY - 2020/4/18/pubmed PY - 2020/7/1/medline PY - 2020/4/18/entrez KW - Angiotensin-converting enzyme 2 KW - Coronavirus disease 2019 KW - Diminazene aceturate (PubChem CID: 5284544) KW - Resorcinolnaphthalein (PubChem CID: 337218) KW - Severe acute respiratory syndrome coronavirus 2 KW - Xanthenone (PubChem CID: 7020) SP - 104833 EP - 104833 JF - Pharmacological research JO - Pharmacol. Res. VL - 157 N2 - The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a negative regulator. Recently, ACE2 was identified as the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that is causing the pandemic of Coronavirus disease 2019 (COVID-19). Since SARS-CoV-2 must bind with ACE2 before entering the host cells in humans, the distribution and expression of ACE2 may be critical for the target organ of the SARS-CoV-2 infection. Moreover, accumulating evidence has demonstrated the implication of ACE2 in the pathological progression in tissue injury and several chronic diseases, ACE2 may also be essential in the progression and clinical outcomes of COVID-19. Therefore, we summarized the expression and activity of ACE2 in various physiological and pathological conditions, and discussed its potential implication in the susceptibility of SARS-CoV-2 infection and the progression and prognosis of COVID-19 patients in the current review. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/32302706/Physiological_and_pathological_regulation_of_ACE2_the_SARS_CoV_2_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(20)31141-5 DB - PRIME DP - Unbound Medicine ER -