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Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China.
J Clin Virol. 2020 06; 127:104353.JC

Abstract

BACKGROUND

The outbreak of a new coronavirus, first reported in Wuhan, China, is spreading around the world. Information on the characteristics of children with Coronavirus Disease 2019 (COVID-19) is limited.

METHODS

In this retrospective study, we recruited 10 children infected with SARS-COV-2 from January 27 to March 10, 2020, in Changsha, China. We report the epidemiological, clinical, laboratory, and high-resolution CT findings for these children. Qualitative descriptive analysis was used to describe the key results.

RESULTS

Ten children were included. Three were male and seven were female. Three were from Wuhan, Hubei Province, and seven were from Changsha. All had a history of close contact with adults with COVID-19 before the onset of disease. Clinical manifestations included fever in four cases, respiratory symptoms in three cases, febrile convulsions in one case, vomiting in one case, abdominal pain in one case, and asymptomatic infection in two cases. All the children tested positive for nucleic acid in throat swabs at admission. Stool swabs of three cases were positive for nucleic acid after several days of fever. In nine children, blood routine results were normal, whereas in one case the white blood cell count was elevated. In four cases, CT findings of the lungs showed light ground-glass opacities, one case showed changes similar to bronchopneumonia, and the remaining cases were normal. All were treated with symptomatic support without complications.

CONCLUSION

Our findings indicate that intrafamily transmission may be the main form of transmission of COVID-19 in children, and persistent intestinal excretion of virus is another characteristic among children. The results of stool swab tests should be considered for discharge and release from isolation.

Authors+Show Affiliations

Division of Pediatrics, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, PR China. Electronic address: tan_yupin@163.com.Division of Clinical Pharmacy, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, 410005, PR China. Electronic address: tanboyu@hunnu.edu.cn.Division of Gastroenterology, Changsha Public Health Rescue Center, North Hospital of Changsha First Hospital, Changsha, 410005, PR China. Electronic address: 344845032@qq.com.Division of Pharmacy, College of Medicine, Hunan Normal University, Changsha, 410005, PR China; Division of Clinical Pharmacy, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, 410005, PR China. Electronic address: 474921585@qq.com.Division of Pediatrics, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, PR China. Electronic address: 55445321@qq.com.Division of Clinical Pharmacy, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, 410005, PR China. Electronic address: weihongyan@hunnu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32302953

Citation

Tan, Yu-Pin, et al. "Epidemiologic and Clinical Characteristics of 10 Children With Coronavirus Disease 2019 in Changsha, China." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 127, 2020, p. 104353.
Tan YP, Tan BY, Pan J, et al. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. J Clin Virol. 2020;127:104353.
Tan, Y. P., Tan, B. Y., Pan, J., Wu, J., Zeng, S. Z., & Wei, H. Y. (2020). Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 127, 104353. https://doi.org/10.1016/j.jcv.2020.104353
Tan YP, et al. Epidemiologic and Clinical Characteristics of 10 Children With Coronavirus Disease 2019 in Changsha, China. J Clin Virol. 2020;127:104353. PubMed PMID: 32302953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. AU - Tan,Yu-Pin, AU - Tan,Bo-Yu, AU - Pan,Jia, AU - Wu,Jing, AU - Zeng,Sai-Zhen, AU - Wei,Hong-Yan, Y1 - 2020/04/10/ PY - 2020/03/19/received PY - 2020/04/03/accepted PY - 2020/4/18/pubmed PY - 2020/6/17/medline PY - 2020/4/18/entrez KW - Clinical characteristics KW - Coronavirus disease 2019 KW - Epidemiologic KW - SARS-COV-2 SP - 104353 EP - 104353 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 127 N2 - BACKGROUND: The outbreak of a new coronavirus, first reported in Wuhan, China, is spreading around the world. Information on the characteristics of children with Coronavirus Disease 2019 (COVID-19) is limited. METHODS: In this retrospective study, we recruited 10 children infected with SARS-COV-2 from January 27 to March 10, 2020, in Changsha, China. We report the epidemiological, clinical, laboratory, and high-resolution CT findings for these children. Qualitative descriptive analysis was used to describe the key results. RESULTS: Ten children were included. Three were male and seven were female. Three were from Wuhan, Hubei Province, and seven were from Changsha. All had a history of close contact with adults with COVID-19 before the onset of disease. Clinical manifestations included fever in four cases, respiratory symptoms in three cases, febrile convulsions in one case, vomiting in one case, abdominal pain in one case, and asymptomatic infection in two cases. All the children tested positive for nucleic acid in throat swabs at admission. Stool swabs of three cases were positive for nucleic acid after several days of fever. In nine children, blood routine results were normal, whereas in one case the white blood cell count was elevated. In four cases, CT findings of the lungs showed light ground-glass opacities, one case showed changes similar to bronchopneumonia, and the remaining cases were normal. All were treated with symptomatic support without complications. CONCLUSION: Our findings indicate that intrafamily transmission may be the main form of transmission of COVID-19 in children, and persistent intestinal excretion of virus is another characteristic among children. The results of stool swab tests should be considered for discharge and release from isolation. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32302953/Epidemiologic_and_clinical_characteristics_of_10_children_with_coronavirus_disease_2019_in_Changsha_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(20)30095-0 DB - PRIME DP - Unbound Medicine ER -